6X5M

Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.

Summary for 6X5M

• Entry DOI: 10.2210/pdb6x5m/pdb
• Descriptor: Light chain Fab BL-3 6, Heavy chain Fab Bl-3 6, ggPAN RNA (39-MER), ... (6 entities in total)
• Functional Keywords: viral encoded rna, rna therapeutics, structure-function studies, small molecules binding, pan triplex, ggene, ggca9, rna, immune system-rna complex, immune system/rna
• Biological source: Mus musculus; More
• Total number of polymer chains: 8
• Total formula weight: 152041.16

Authors

Swain, M.,Li, M.,Wlodawer, A.,Le Grice, S.F.J. (deposition date: 2020-05-26, release date: 2020-06-24, Last modification date: 2023-10-18)

• Primary citation: Swain, M.,Ageeli, A.A.,Kasprzak, W.K.,Li, M.,Miller, J.T.,Sztuba-Solinska, J.,Schneekloth, J.S.,Koirala, D.,Piccirili, J.,Fraboni, A.J.,Murelli, R.P.,Wlodawer, A.,Shapiro, B.A.,Baird, N.,Le Grice, S.F.J.; Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands.; Nucleic Acids Res., 49:13179-13193, 2021; PubMed: 34871450; DOI: 10.1093/nar/gkab1170

Experimental method

X-RAY DIFFRACTION (2.5 Å)