8R4V

Structure of Salt-inducible kinase 3 in complex with inhibitor

Summary for 8R4V

Entry DOI	10.2210/pdb8r4v/pdb
Descriptor	Serine/threonine-protein kinase SIK3, 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea (3 entities in total)
Functional Keywords	kinase, ampk-like, uba, inhibitor complex, drug design, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	115369.60
Authors	Kack, H.,Oster, L. (deposition date: 2023-11-14, release date: 2024-03-27, Last modification date: 2024-04-03)
Primary citation	Oster, L.,Castaldo, M.,de Vries, E.,Edfeldt, F.,Pemberton, N.,Gordon, E.,Cederblad, L.,Kack, H. The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., :107201-107201, 2024 Cited by PubMed: 38508313 DOI: 10.1016/j.jbc.2024.107201 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation