8R4V
Structure of Salt-inducible kinase 3 in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Serine/threonine-protein kinase SIK3 | polymer | 328 | 37888.9 | 3 | UniProt (Q9Y2K2) Pfam (PF00069) In PDB | Homo sapiens (human) | |
2 | A, B, C | 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea | non-polymer | 567.7 | 3 | Chemie (XWA) | |||
3 | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B, C: 59 - 385 (UniProt: Q9Y2K2)
PDB | External Database | Details |
---|---|---|
Ser 58 | - | expression tag |
Ser 121 | Cys 121 | engineered mutation |
Ser 181 | Cys 181 | engineered mutation |
Ser 333 | Cys 333 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 113666.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1703.0 | |
All* | Total formula weight | 115369.6 |