6IYC
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![BU of 6iyc by Molmil](/molmil-images/mine/6iyc) | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | Deposit date: | 2018-12-14 | Release date: | 2019-01-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
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6XYO
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![BU of 6xyo by Molmil](/molmil-images/mine/6xyo) | Multiple system atrophy Type I alpha-synuclein filament | Descriptor: | Alpha-synuclein | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2020-01-30 | Release date: | 2020-02-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6X93
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![BU of 6x93 by Molmil](/molmil-images/mine/6x93) | Interleukin-10 signaling complex with IL-10RA and IL-10RB | Descriptor: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | Authors: | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | Deposit date: | 2020-06-02 | Release date: | 2021-03-17 | Last modified: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science, 371, 2021
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7VIG
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![BU of 7vig by Molmil](/molmil-images/mine/7vig) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIE
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![BU of 7vie by Molmil](/molmil-images/mine/7vie) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIF
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![BU of 7vif by Molmil](/molmil-images/mine/7vif) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIH
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![BU of 7vih by Molmil](/molmil-images/mine/7vih) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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3DQV
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![BU of 3dqv by Molmil](/molmil-images/mine/3dqv) | Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation | Descriptor: | Cullin-5, NEDD8, Rbx1, ... | Authors: | Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A. | Deposit date: | 2008-07-09 | Release date: | 2008-09-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell(Cambridge,Mass.), 134, 2008
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4HPT
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![BU of 4hpt by Molmil](/molmil-images/mine/4hpt) | Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | Deposit date: | 2012-10-24 | Release date: | 2013-03-20 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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4HPU
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![BU of 4hpu by Molmil](/molmil-images/mine/4hpu) | Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying partial phosphoryl transfer of AMP-PNP onto a substrate peptide | Descriptor: | MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Bastidas, A.C, Steichen, J.M, Wu, J, Taylor, S.S. | Deposit date: | 2012-10-24 | Release date: | 2013-03-20 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc., 135, 2013
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4F3L
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![BU of 4f3l by Molmil](/molmil-images/mine/4f3l) | Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex | Descriptor: | BMAL1b, Circadian locomoter output cycles protein kaput | Authors: | Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J. | Deposit date: | 2012-05-09 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.268 Å) | Cite: | Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science, 337, 2012
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5YDD
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![BU of 5ydd by Molmil](/molmil-images/mine/5ydd) | Crystal structure of C-terminal domain of Rv1828 from Mycobacterium tuberculosis | Descriptor: | (6R,8S,9S)-8-(hydroxymethyl)-6,11,11-tris(oxidanyl)-9-propyl-dodecanoic acid, GLYCEROL, SODIUM ION, ... | Authors: | Singh, S, Karthiekeyan, S. | Deposit date: | 2017-09-12 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Characteristics of the essential pathogenicity factor Rv1828, a MerR family transcription regulator from Mycobacterium tuberculosis. FEBS J., 285, 2018
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3EMH
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![BU of 3emh by Molmil](/molmil-images/mine/3emh) | Structural basis of WDR5-MLL interaction | Descriptor: | Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5 | Authors: | Song, J.J, Kingston, R.E. | Deposit date: | 2008-09-24 | Release date: | 2008-10-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. J.Biol.Chem., 283, 2008
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7V4C
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![BU of 7v4c by Molmil](/molmil-images/mine/7v4c) | |
7V47
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![BU of 7v47 by Molmil](/molmil-images/mine/7v47) | |
7V48
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7V4A
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![BU of 7v4a by Molmil](/molmil-images/mine/7v4a) | |
7V4D
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![BU of 7v4d by Molmil](/molmil-images/mine/7v4d) | Heparin-remodelled alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Tao, Y.Q, Sun, Y.P, Xia, W.C, Zhao, Q.Y, Liu, C, Li, D. | Deposit date: | 2021-08-12 | Release date: | 2022-08-17 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Heparin-remodelled alpha-synuclein fibrils To Be Published
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7V49
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![BU of 7v49 by Molmil](/molmil-images/mine/7v49) | |
5YDC
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![BU of 5ydc by Molmil](/molmil-images/mine/5ydc) | |
6XYP
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![BU of 6xyp by Molmil](/molmil-images/mine/6xyp) | Multiple system atrophy Type II-1 alpha-synuclein filament | Descriptor: | Alpha-synuclein | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2020-01-30 | Release date: | 2020-02-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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8A9G
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![BU of 8a9g by Molmil](/molmil-images/mine/8a9g) | Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1 | Descriptor: | 14-3-3 protein zeta/delta, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, ... | Authors: | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | Deposit date: | 2022-06-28 | Release date: | 2022-12-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.961 Å) | Cite: | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
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1LV9
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![BU of 1lv9 by Molmil](/molmil-images/mine/1lv9) | CXCR3 Binding Chemokine IP-10/CXCL10 | Descriptor: | Small inducible cytokine B10 | Authors: | Booth, V, Keizer, D.W, Kamphuis, M.B, Clark-Lewis, I, Sykes, B.D. | Deposit date: | 2002-05-27 | Release date: | 2002-09-18 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry, 41, 2002
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3B4V
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![BU of 3b4v by Molmil](/molmil-images/mine/3b4v) | X-Ray structure of Activin in complex with FSTL3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... | Authors: | Thompson, T.B. | Deposit date: | 2007-10-24 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
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5JR7
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![BU of 5jr7 by Molmil](/molmil-images/mine/5jr7) | Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit | Authors: | Bruystens, J.G.H, Wu, J, Taylor, S.S. | Deposit date: | 2016-05-05 | Release date: | 2017-03-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.56 Å) | Cite: | Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428, 2016
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