8A9G
Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1
Summary for 8A9G
Entry DOI | 10.2210/pdb8a9g/pdb |
Related | 6YO8 |
Descriptor | 14-3-3 protein zeta/delta, Glucocorticoid receptor, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
Functional Keywords | 14-3-3 protein zeta/delta, glucocorticoid receptor, (r)-para chloropyrrolidone1, protein-peptide complex, protein-protein interaction, ppi stabilisation, molecular glue, pyrrolidone1 analogue, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 57792.18 |
Authors | Munier, C.C.,Edman, K.,Perry, M.W.D.,Ottmann, C. (deposition date: 2022-06-28, release date: 2022-12-28, Last modification date: 2024-01-31) |
Primary citation | Pallesen, J.S.,Munier, C.C.,Bosica, F.,Andrei, S.A.,Edman, K.,Gunnarsson, A.,La Sala, G.,Putra, O.D.,Srdanovic, S.,Wilson, A.J.,Wissler, L.,Ottmann, C.,Perry, M.W.D.,O'Mahony, G. Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65:16818-16828, 2022 Cited by PubMed: 36484727DOI: 10.1021/acs.jmedchem.2c01635 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.961 Å) |
Structure validation
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