5JR7

Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA

Summary for 5JR7

Entry DOI	10.2210/pdb5jr7/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	pka signaling, ria subunit, disease mutations, dysfunctional acrdys mutant, transferase-camp binding protein complex, transferase/camp binding protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	144155.18
Authors	Bruystens, J.G.H.,Wu, J.,Taylor, S.S. (deposition date: 2016-05-05, release date: 2017-03-15, Last modification date: 2023-09-27)
Primary citation	Bruystens, J.G.,Wu, J.,Fortezzo, A.,Del Rio, J.,Nielsen, C.,Blumenthal, D.K.,Rock, R.,Stefan, E.,Taylor, S.S. Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428:4890-4904, 2016 Cited by PubMed: 27825928 DOI: 10.1016/j.jmb.2016.10.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.56 Å)

Structure validation