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5JR7

Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016310biological_processphosphorylation
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030145molecular_functionmanganese ion binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034605biological_processcellular response to heat
A0036126cellular_componentsperm flagellum
A0044853cellular_componentplasma membrane raft
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0051726biological_processregulation of cell cycle
A0061136biological_processregulation of proteasomal protein catabolic process
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0097546cellular_componentciliary base
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A0141156biological_processcAMP/PKA signal transduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
B0001932biological_processregulation of protein phosphorylation
B0005952cellular_componentcAMP-dependent protein kinase complex
B0008603molecular_functioncAMP-dependent protein kinase regulator activity
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000287molecular_functionmagnesium ion binding
C0001669cellular_componentacrosomal vesicle
C0001707biological_processmesoderm formation
C0001843biological_processneural tube closure
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004679molecular_functionAMP-activated protein kinase activity
C0004691molecular_functioncAMP-dependent protein kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0006611biological_processprotein export from nucleus
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0016310biological_processphosphorylation
C0016607cellular_componentnuclear speck
C0018105biological_processpeptidyl-serine phosphorylation
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030145molecular_functionmanganese ion binding
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031594cellular_componentneuromuscular junction
C0031625molecular_functionubiquitin protein ligase binding
C0032024biological_processpositive regulation of insulin secretion
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034605biological_processcellular response to heat
C0036126cellular_componentsperm flagellum
C0044853cellular_componentplasma membrane raft
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045667biological_processregulation of osteoblast differentiation
C0045722biological_processpositive regulation of gluconeogenesis
C0045879biological_processnegative regulation of smoothened signaling pathway
C0046827biological_processpositive regulation of protein export from nucleus
C0048240biological_processsperm capacitation
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0051726biological_processregulation of cell cycle
C0061136biological_processregulation of proteasomal protein catabolic process
C0070417biological_processcellular response to cold
C0070613biological_processregulation of protein processing
C0071333biological_processcellular response to glucose stimulus
C0071374biological_processcellular response to parathyroid hormone stimulus
C0071377biological_processcellular response to glucagon stimulus
C0097546cellular_componentciliary base
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C0141156biological_processcAMP/PKA signal transduction
C1904262biological_processnegative regulation of TORC1 signaling
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C1990044biological_processprotein localization to lipid droplet
C2000810biological_processregulation of bicellular tight junction assembly
D0001932biological_processregulation of protein phosphorylation
D0005952cellular_componentcAMP-dependent protein kinase complex
D0008603molecular_functioncAMP-dependent protein kinase regulator activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue ADP A 400
ChainResidue
AGLY50
AGLU127
AGLU170
AASN171
ALEU173
ATHR183
AASP184
APHE327
AGLY52
AGLY55
AVAL57
AALA70
ALYS72
AMET120
AGLU121
AVAL123

site_idAC2
Number of Residues13
Detailsbinding site for residue ADP C 400
ChainResidue
CGLY50
CGLY52
CGLY55
CVAL57
CALA70
CLYS72
CGLU121
CVAL123
CGLU127
CGLU170
CLEU173
CTHR183
CASP184

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
ALEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU162-ILE174

site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIqQGDeGDnFYVIdqG
ChainResidueDetails
BVAL162-GLY178
BILE280-GLY296

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALiygtp......RAAtVkA
ChainResidueDetails
BPHE198-ALA215
BPHE322-ALA339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING:
ChainResidueDetails
BLEU135
DILE253
DGLU324
DARG333
BGLU200
BARG209
BILE253
BGLU324
BARG333
DLEU135
DGLU200
DARG209

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DBC7
ChainResidueDetails
BSER99
DSER99
AGLU121
ALYS168
CLEU49
CLYS72
CGLU121
CLYS168

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09456
ChainResidueDetails
BSER256
DSER256

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:11141074, ECO:0000269|PubMed:8395513
ChainResidueDetails
ASER10
CSER10

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612
ChainResidueDetails
ATHR48
ATHR195
CTHR48
CTHR195

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22323819, ECO:0000305|PubMed:8395513
ChainResidueDetails
ASEP139
CSEP139

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
ATPO197
CTPO197

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
ATYR330
CTYR330

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
ASEP338
CSEP338

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:11141074
ChainResidueDetails
AGLY1
CGLY1

226707

PDB entries from 2024-10-30

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