PDB: 499 resultsInfo pagesStatus searchChemie searchBIRD

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7SSA	Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ... Authors: Eek, P, Tan, S. Deposit date: 2021-11-10 Release date: 2023-04-05 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions. Mol.Cell, 83, 2023
3PXP	Crystal structure of a PAS and DNA binding domain containing protein (Caur_2278) from CHLOROFLEXUS AURANTIACUS J-10-FL at 2.30 A resolution Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Helix-turn-helix domain protein, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2010-12-10 Release date: 2011-01-19 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes. Plos One, 7, 2012
4ZPR	Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-08 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.902 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZPK	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA Descriptor: Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-08 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZP4	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-07 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.355 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZPH	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-07 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
4ZQD	Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine Authors: Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. Deposit date: 2015-05-09 Release date: 2015-08-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Structural integration in hypoxia-inducible factors. Nature, 524, 2015
5ZD4	Crystal structure of MBP-fused BIL1/BZR1 in complex with double-stranded DNA Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*TP*TP*CP*AP*CP*AP*CP*GP*TP*GP*TP*GP*AP*AP*A)-3'), Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Nosaki, S, Miyakawa, T, Xu, Y, Nakamura, A, Hirabayashi, K, Tanokura, M. Deposit date: 2018-02-22 Release date: 2018-08-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structural basis for brassinosteroid response by BIL1/BZR1. Nat Plants, 4, 2018
6A5Q	Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif Descriptor: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide Authors: Xu, Y, Ren, J.Q, Feng, W. Deposit date: 2018-06-25 Release date: 2019-02-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
6A5S	Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif Descriptor: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... Authors: Xu, Y, Ren, J.Q, Feng, W. Deposit date: 2018-06-25 Release date: 2019-02-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.099 Å) Cite: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
6MGM	Helix-Loop-helix motif of mouse DNA-binding protein inhibitor ID-1 Descriptor: DNA-binding protein inhibitor ID-1 Authors: Benezra, R, Pavletich, N.P, Goldgur, Y, Gall, A.-L. Deposit date: 2018-09-14 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.791 Å) Cite: A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
4KFZ	Crystal structure of LMO2 and anti-LMO2 VH complex Descriptor: Anti-LMO2 VH, LMO-2, ZINC ION Authors: Sewell, H, Tanaka, T, El Omari, K, Cruz-Migoni, A, Mancini, E.J, Fuentes-Fernandez, N, Chambers, J, Rabbitts, T.H. Deposit date: 2013-04-28 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep, 4, 2014
7F2F	The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7 Authors: Gui, W. Deposit date: 2021-06-10 Release date: 2021-10-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 77, 2021
7VNI	AHR-ARNT PAS-B heterodimer Descriptor: Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION Authors: Dai, S.Y. Deposit date: 2021-10-11 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.997 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
7VNA	drosophlia AHR PAS-B domain Descriptor: Ahr homolog spineless Authors: Dai, S.Y. Deposit date: 2021-10-10 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.597 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
7VNH	drosophlia AHR PAS-B domain bound by the antagonist alpha-naphthoflavone Descriptor: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Ahr homolog spineless Authors: Dai, S.Y. Deposit date: 2021-10-11 Release date: 2022-04-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.402 Å) Cite: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
8QMO	Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... Authors: Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J. Deposit date: 2023-09-24 Release date: 2024-01-10 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds. J.Mol.Biol., 436, 2024
4GS9	Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ... Authors: Scheuermann, T.H, Gardner, K.H. Deposit date: 2012-08-27 Release date: 2013-04-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor J.Med.Chem., 56, 2013
6X28	Crystal structure of PT2243 bound to HIF2a-B*:ARNT-B* complex Descriptor: (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-20 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Crystal structure of PT2243 bound to HIF2-PasB*:ARNT-PasB* complex To Be Published
6X37	Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex Descriptor: 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-21 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex To Be Published
6X2H	Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, cis-3-({(1S)-7-[dihydroxy(trifluoromethyl)-lambda~4~-sulfanyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)cyclobutane-1-carbonitrile Authors: Du, X. Deposit date: 2020-05-20 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex To Be Published
6X3D	Crystal structure of PT3388 bound to HIF2a-B*:ARNT-B* complex Descriptor: (6R,7S)-4-[(3,3-difluorocyclobutyl)oxy]-6-fluoro-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-21 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of PT3388 bound to HIF2a-B*:ARNT-B* complex To Be Published
6X21	Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex Descriptor: 1-(3-bromo-5-fluorophenoxy)-4-[(difluoromethyl)sulfonyl]-2-nitrobenzene, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 Authors: Du, X. Deposit date: 2020-05-19 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Crystal structure of PT1673 bound to HIF2a-B*:ARNT-B* complex To Be Published
6NX1	STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC CO-ACTIVATOR PEPTIDE AND COMPOUND-3 AKA 1,1,1,3,3,3-HEXAFLUORO-2-{4-[1-(4- LUOROBENZENESULFONYL)CYCLOPENTYL]PHENYL}PROPAN-2-OL Descriptor: 1,1,1,3,3,3-hexafluoro-2-(4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}phenyl)propan-2-ol, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion Authors: Khan, J.A. Deposit date: 2019-02-07 Release date: 2020-02-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 10, 2019
5X0R	Crystal Structure of PXR LBD Complexed with SJB7 Descriptor: 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 Authors: Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T. Deposit date: 2017-01-23 Release date: 2017-10-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.665 Å) Cite: SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun, 8, 2017

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