Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine

Summary for 4ZPH

Related4ZP4 4ZPK 4ZPR
DescriptorAryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN, ... (4 entities in total)
Functional Keywordshif-2a, arnt, bhlh-pas, proflavine, protein transport-transcription complex, protein transport/transcription
Biological sourceMus musculus (Mouse)
Cellular locationNucleus P53762 P97481
Total number of polymer chains4
Total molecular weight169485.94
Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F. (deposition date: 2015-05-07, release date: 2015-08-12, Last modification date: 2015-08-26)
Primary citation
Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F.
Structural integration in hypoxia-inducible factors.
Nature, 524:303-308, 2015
PubMed: 26245371 (PDB entries with the same primary citation)
DOI: 10.1038/nature14883
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.219190 0.4% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21