4ZPH
Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Aryl hydrocarbon receptor nuclear translocator | polymer | 384 | 43437.4 | 2 | UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) In PDB | Mus musculus (Mouse) | ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta |
| 2 | B, D | Endothelial PAS domain-containing protein 1 | polymer | 360 | 41201.0 | 2 | UniProt (P97481) Pfam (PF00989) Pfam (PF14598) In PDB | Mus musculus (Mouse) | EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF2-alpha |
| 3 | A | PROFLAVIN | non-polymer | 209.2 | 1 | Chemie (PRL) | |||
| 4 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, C: 82 - 464 (UniProt: P53762)
B, D: 3 - 361 (UniProt: P97481)
| PDB | External Database | Details |
|---|---|---|
| Met 81 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 169276.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 209.2 | |
| All* | Total formula weight | 169485.9 |
