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2REU
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BU of 2reu by Molmil
Crystal Structure of the C-terminal of Sau3AI fragment
Descriptor: MAGNESIUM ION, Type II restriction enzyme Sau3AI
Authors:Hu, X, Yu, F, Xu, C, He, J.
Deposit date:2007-09-27
Release date:2008-09-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and function of C-terminal Sau3AI domain
Biochim.Biophys.Acta, 1794, 2009
1K1K
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BU of 1k1k by Molmil
Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer.
Descriptor: CARBON MONOXIDE, HEMOGLOBIN ALPHA CHAIN, HEMOGLOBIN BETA CHAIN, ...
Authors:Dewan, J.C, Taylor-Feeling, A, Puius, Y.A, Patskovska, L, Patskovsky, Y, Nagel, R.L, Almo, S.C, Hirsch, R.E.
Deposit date:2001-09-25
Release date:2002-12-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution.
Acta Crystallogr.,Sect.D, 58, 2002
1Z5Y
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BU of 1z5y by Molmil
Crystal Structure Of The Disulfide-Linked Complex Between The N-Terminal Domain Of The Electron Transfer Catalyst DsbD and The Cytochrome c Biogenesis Protein CcmG
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Thiol:disulfide interchange protein dsbD, ...
Authors:Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Gruetter, M.G, Glockshuber, R, Capitani, G.
Deposit date:2005-03-21
Release date:2005-07-19
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural Basis and Kinetics of DsbD-Dependent Cytochrome c Maturation
STRUCTURE, 13, 2005
1ZH1
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BU of 1zh1 by Molmil
Structure of the zinc-binding domain of HCV NS5A
Descriptor: ZINC ION, non-structural polyprotein
Authors:Tellinghuisen, T.L, Marcotrigiano, J, Rice, C.M.
Deposit date:2005-04-22
Release date:2005-05-24
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase.
Nature, 435, 2005
2YKI
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BU of 2yki by Molmil
Tricyclic series of Hsp90 inhibitors
Descriptor: 1-H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID [4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-AMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-27
Release date:2011-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2GIR
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BU of 2gir by Molmil
Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor
Descriptor: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase
Authors:Harris, S.F.
Deposit date:2006-03-29
Release date:2007-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
J.Virol., 80, 2006
3V46
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BU of 3v46 by Molmil
Crystal Structure of Yeast Cdc73 C-Terminal Domain
Descriptor: Cell division control protein 73
Authors:Amrich, C.G, VanDemark, A.P.
Deposit date:2011-12-14
Release date:2012-02-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.
J.Biol.Chem., 287, 2012
2K2J
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BU of 2k2j by Molmil
NMR solution structure of the split PH domain from Phospholipase C gamma 2
Descriptor: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
Authors:Harris, R, Bunney, T.D, Katan, M, Driscoll, P.C.
Deposit date:2008-04-02
Release date:2008-09-09
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Rac Regulates Its Effector Phospholipase C{gamma}2 through Interaction with a Split Pleckstrin Homology Domain.
J.Biol.Chem., 283, 2008
2YKJ
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Tricyclic series of Hsp90 inhibitors
Descriptor: 2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA
Authors:Dupuy, A, Vallee, F.
Deposit date:2011-05-27
Release date:2011-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.
J.Med.Chem., 54, 2011
2MGX
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BU of 2mgx by Molmil
NMR structure of SRA1p C-terminal domain
Descriptor: Steroid receptor RNA activator 1
Authors:Bilinovich, S.M, Davis, C.M, Morris, D.L, Ray, L.A, Prokop, J.W, Buchan, G.J, Leeper, T.C.
Deposit date:2013-11-10
Release date:2014-02-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The C-Terminal Domain of SRA1p Has a Fold More Similar to PRP18 than to an RRM and Does Not Directly Bind to the SRA1 RNA STR7 Region.
J.Mol.Biol., 426, 2014
4BH6
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BU of 4bh6 by Molmil
Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex
Descriptor: APC/C ACTIVATOR PROTEIN CDH1, APC/C-CDH1 MODULATOR 1
Authors:He, J, Chao, W.C.H, Zhang, Z, Yang, J, Cronin, N, Barford, D.
Deposit date:2013-03-29
Release date:2013-06-05
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights Into Degron Recognition by Apc/C Coactivators from the Structure of an Acm1-Cdh1 Complex.
Mol.Cell, 50, 2013
5TZD
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BU of 5tzd by Molmil
Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein
Authors:Schumacher, M.
Deposit date:2016-11-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
3JTC
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BU of 3jtc by Molmil
Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ...
Authors:Bajaj, S.P, Vadivel, K, Agah, S, Cascio, D, Krishnaswamy, S, Esmon, C, Padmanabhan, K.
Deposit date:2009-09-11
Release date:2011-04-06
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
J.Mol.Biol., 425, 2013
3JBT
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BU of 3jbt by Molmil
Atomic structure of the Apaf-1 apoptosome
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ...
Authors:Zhou, M, Li, Y, Hu, Q, Bai, X, Huang, W, Yan, C, Scheres, S.H.W, Shi, Y.
Deposit date:2015-10-15
Release date:2015-11-18
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
Genes Dev., 29, 2015
4TYD
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BU of 4tyd by Molmil
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease
Descriptor: (4R,6S,7Z,15S,17S)-17-[({7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)methyl]-13-methyl-N-[(1-methylcyclopropyl)sulfonyl]-2,14-dioxo-1,3,13-triazatricyclo[13.2.0.0~4,6~]heptadec-7-ene-4-carboxamide, CHLORIDE ION, NS3 protease, ...
Authors:Parsy, C.
Deposit date:2014-07-08
Release date:2014-09-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg.Med.Chem.Lett., 24, 2014
2SNI
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BU of 2sni by Molmil
STRUCTURAL COMPARISON OF TWO SERINE PROTEINASE-PROTEIN INHIBITOR COMPLEXES. EGLIN-C-SUBTILISIN CARLSBERG AND CI-2-SUBTILISIN NOVO
Descriptor: CALCIUM ION, CHYMOTRYPSIN INHIBITOR 2, SUBTILISIN NOVO
Authors:Mcphalen, C.A, James, M.N.G.
Deposit date:1988-09-05
Release date:1988-09-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo.
Biochemistry, 27, 1988
1KQL
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BU of 1kql by Molmil
Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution
Descriptor: Fusion Protein of and striated muscle alpha-tropomyosin and the GCN4 leucine zipper
Authors:Li, Y, Mui, S, Brown, J.H, Strand, J, Reshetnikova, L, Tobacman, L.S, Cohen, C.
Deposit date:2002-01-07
Release date:2002-05-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site.
Proc.Natl.Acad.Sci.USA, 99, 2002
4I33
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BU of 4i33 by Molmil
Crystal structure of HCV NS3/4A R155K protease complexed with compound 4
Descriptor: (2R,6S,7E,10E,13aR,14aR,16aS)-2-{[7-methoxy-8-methyl-2-(propan-2-yloxy)quinolin-4-yl]oxy}-N-[(1-methylcyclopropyl)sulfonyl]-6-{[(1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-5,16-dioxo-1,2,3,6,9,12,13,13a,14,15,16,16a-dodecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, Genome polyprotein, HCV non-structural protein 4A, ...
Authors:Lemke, C.T.
Deposit date:2012-11-23
Release date:2013-01-02
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.9001 Å)
Cite:Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.
J.Biol.Chem., 288, 2013
2MTA
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BU of 2mta by Molmil
CRYSTAL STRUCTURE OF A TERNARY ELECTRON TRANSFER COMPLEX BETWEEN METHYLAMINE DEHYDROGENASE, AMICYANIN AND A C-TYPE CYTOCHROME
Descriptor: AMICYANIN, COPPER (II) ION, CYTOCHROME C551I, ...
Authors:Chen, L, Mathews, F.S.
Deposit date:1993-10-26
Release date:1994-01-31
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an electron transfer complex: methylamine dehydrogenase, amicyanin, and cytochrome c551i.
Science, 264, 1994
2K7X
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BU of 2k7x by Molmil
solution structure of C-terminal domain of SARS-CoV main protease
Descriptor: SARS-CoV main protease
Authors:Xia, B, Zhong, N.
Deposit date:2008-08-28
Release date:2009-05-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer.
Protein Sci., 18, 2009
1R0P
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BU of 1r0p by Molmil
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Descriptor: Hepatocyte growth factor receptor, K-252A
Authors:Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C.
Deposit date:2003-09-22
Release date:2003-10-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Proc.Natl.Acad.Sci.USA, 100, 2003
2OR9
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BU of 2or9 by Molmil
The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops
Descriptor: Monoclonal anti-c-myc antibody 9E10, synthetic epitope peptide of 9E10
Authors:Krauss, N, Scheerer, P, Hoehne, W.
Deposit date:2007-02-02
Release date:2008-02-12
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops.
Proteins, 73, 2008
2AIU
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BU of 2aiu by Molmil
Crystal Structure of Mouse Testicular Cytochrome C at 1.6 Angstrom
Descriptor: Cytochrome c, testis-specific, PHOSPHATE ION, ...
Authors:Liu, Z, Ye, S, Lin, H, Rao, Z, Liu, X.J.
Deposit date:2005-08-01
Release date:2006-07-18
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis
Proc.Natl.Acad.Sci.Usa, 103, 2006
2EB1
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BU of 2eb1 by Molmil
Crystal Structure of the C-Terminal RNase III Domain of Human Dicer
Descriptor: Endoribonuclease Dicer, MAGNESIUM ION
Authors:Takeshita, D, Zenno, S, Lee, W.C, Nagata, K, Saigo, K, Tanokura, M.
Deposit date:2007-02-05
Release date:2007-11-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Homodimeric Structure and Double-stranded RNA Cleavage Activity of the C-terminal RNase III Domain of Human Dicer
J.Mol.Biol., 374, 2007
3SU0
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BU of 3su0 by Molmil
Crystal structure of NS3/4A protease variant R155K in complex with danoprevir
Descriptor: (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, Genome polyprotein, SULFATE ION, ...
Authors:Schiffer, C.A, Romano, K.P.
Deposit date:2011-07-11
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.159 Å)
Cite:The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
Plos Pathog., 8, 2012

238582

数据于2025-07-09公开中

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