Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3JTC

Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins

Summary for 3JTC
Entry DOI10.2210/pdb3jtc/pdb
DescriptorEndothelial protein C receptor, Vitamin K-dependent protein C, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsgla (gamma-carboxyglutamic acid) residues, phospholipid binding groove, ca ion binding, blood clotting, blood coagulation, disulfide bond, glycoprotein, membrane, receptor, transmembrane, cleavage on pair of basic residues, disease mutation, egf-like domain, gamma-carboxyglutamic acid, hydrolase, hydroxylation, protease, serine protease, thrombophilia, zymogen
Biological sourceHOMO SAPIENS (human)
More
Total number of polymer chains4
Total formula weight56105.27
Authors
Bajaj, S.P.,Vadivel, K.,Agah, S.,Cascio, D.,Krishnaswamy, S.,Esmon, C.,Padmanabhan, K. (deposition date: 2009-09-11, release date: 2011-04-06, Last modification date: 2020-07-29)
Primary citationVadivel, K.,Agah, S.,Messer, A.S.,Cascio, D.,Bajaj, M.S.,Krishnaswamy, S.,Esmon, C.T.,Padmanabhan, K.,Bajaj, S.P.
Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
J.Mol.Biol., 425:1961-1981, 2013
Cited by
PubMed: 23454357
DOI: 10.1016/j.jmb.2013.02.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon