2GIR

Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor

Summary for 2GIR

• Entry DOI: 10.2210/pdb2gir/pdb
• Related: 2GIQ
• Descriptor: RNA-directed RNA polymerase, 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: hcv, hepatitis, ns5b, transferase rna-dependent rna polymerase, transferase
• Biological source: Hepatitis C virus (isolate BK)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• Total number of polymer chains: 2
• Total formula weight: 127270.15

Authors

Harris, S.F. (deposition date: 2006-03-29, release date: 2007-04-03, Last modification date: 2024-02-14)

• Primary citation: Le Pogam, S.,Kang, H.,Harris, S.F.,Leveque, V.,Giannetti, A.M.,Ali, S.,Jiang, W.R.,Rajyaguru, S.,Tavares, G.,Oshiro, C.,Hendricks, T.,Klumpp, K.,Symons, J.,Browner, M.F.,Cammack, N.,Najera, I.; Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.; J.Virol., 80:6146-6154, 2006; PubMed: 16731953; DOI: 10.1128/JVI.02628-05

Experimental method

X-RAY DIFFRACTION (1.9 Å)