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2GIR

Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NN3 A 1001
ChainResidue
ALEU419
AARG422
AHIS475
ASER476
ATYR477
AILE482
ATRP528
AHOH1169

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NN3 B 2001
ChainResidue
BARG422
BHIS475
BSER476
BTYR477
BTRP528
BHOH2201
BHOH2253
BLEU419

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
ATHR221
AASP319
ALEU320
BTHR221
BASP319
BLEU320

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ALEU30
AARG43
BLEU30
BARG43

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PDB entries from 2024-11-06

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