5IS0
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![BU of 5is0 by Molmil](/molmil-images/mine/5is0) | Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 1, capsazepine | Authors: | Gao, Y, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2016-03-15 | Release date: | 2016-05-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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8T3M
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![BU of 8t3m by Molmil](/molmil-images/mine/8t3m) | TRPV1 in nanodisc bound with 3 LPA molecules | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T3L
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![BU of 8t3l by Molmil](/molmil-images/mine/8t3l) | TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0E
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![BU of 8t0e by Molmil](/molmil-images/mine/8t0e) | TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo) | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-05-31 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0C
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![BU of 8t0c by Molmil](/molmil-images/mine/8t0c) | |
8T10
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![BU of 8t10 by Molmil](/molmil-images/mine/8t10) | TRPV1 in nanodisc bound with two LPA molecules in opposite monomers | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0Y
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![BU of 8t0y by Molmil](/molmil-images/mine/8t0y) | TRPV1 in nanodisc bound with one LPA in one monomer | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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1WAP
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![BU of 1wap by Molmil](/molmil-images/mine/1wap) | |
8U3L
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![BU of 8u3l by Molmil](/molmil-images/mine/8u3l) | |
8U3A
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![BU of 8u3a by Molmil](/molmil-images/mine/8u3a) | TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 1 (monomer) | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U30
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![BU of 8u30 by Molmil](/molmil-images/mine/8u30) | TRPV1 in nanodisc bound with diC8-PIP2 in the closed state | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily V member 1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U3C
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![BU of 8u3c by Molmil](/molmil-images/mine/8u3c) | TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 2 (monomer) | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8FC7
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![BU of 8fc7 by Molmil](/molmil-images/mine/8fc7) | Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC9
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![BU of 8fc9 by Molmil](/molmil-images/mine/8fc9) | Cryo-EM structure of the human TRPV4 - RhoA, apo condition | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FCA
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![BU of 8fca by Molmil](/molmil-images/mine/8fca) | Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate | Descriptor: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC8
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![BU of 8fc8 by Molmil](/molmil-images/mine/8fc8) | Cryo-EM structure of the human TRPV4 in complex with GSK1016790A | Descriptor: | CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FCB
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![BU of 8fcb by Molmil](/molmil-images/mine/8fcb) | Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8U2Z
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![BU of 8u2z by Molmil](/molmil-images/mine/8u2z) | TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U43
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![BU of 8u43 by Molmil](/molmil-images/mine/8u43) | TRPV1 in nanodisc bound with PIP2-Br4 | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-08 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U4D
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![BU of 8u4d by Molmil](/molmil-images/mine/8u4d) | TRPV1 in nanodisc bound with PI-Br4, consensus structure | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-10 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U3J
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![BU of 8u3j by Molmil](/molmil-images/mine/8u3j) | |
5AN8
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![BU of 5an8 by Molmil](/molmil-images/mine/5an8) | Cryo-electron microscopy structure of rabbit TRPV2 ion channel | Descriptor: | TRPV2 | Authors: | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | Deposit date: | 2015-09-04 | Release date: | 2015-12-23 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-Electron Microscopy of the Trpv2 Ion Channel Nat.Struct.Mol.Biol., 23, 2016
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2JOF
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![BU of 2jof by Molmil](/molmil-images/mine/2jof) | |
1TRP
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![BU of 1trp by Molmil](/molmil-images/mine/1trp) | |
6BWF
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![BU of 6bwf by Molmil](/molmil-images/mine/6bwf) | 4.1 angstrom Mg2+-unbound structure of mouse TRPM7 | Descriptor: | TRPM7 | Authors: | Zhang, J, Li, Z, Duan, J, Abiria, S.A, Clapham, D.E. | Deposit date: | 2017-12-14 | Release date: | 2018-08-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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