PDB: 289 resultsInfo pagesStatus searchChemie searchBIRD

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5IPN	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2016-06-22 Method: X-RAY DIFFRACTION (4.61 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
5VOI	X-ray crystal structure of bacterial RNA polymerase and pyrG promoter complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. Deposit date: 2017-05-02 Release date: 2017-05-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W1S	X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.805 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
8HIH	Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J, Xu, J.C. Deposit date: 2022-11-20 Release date: 2023-06-07 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
5IPM	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2016-06-22 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
6CUU	Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Murakami, K.S. Deposit date: 2018-03-26 Release date: 2018-07-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.994 Å) Cite: Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Molodtsov, V, Murakami, K.S. Deposit date: 2018-03-26 Release date: 2018-07-25 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (4.104 Å) Cite: Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
5W1T	X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
8IGR	Cryo-EM structure of CII-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
8IGS	Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A Descriptor: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2018-05-06 Release date: 2018-09-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.993 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
5IPL	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
4G7Z	Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1 Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.815 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
7PP4	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-09-13 Release date: 2022-09-21 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
8HVR	Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2022-12-27 Release date: 2023-12-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Descriptor: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2022-10-12 Method: X-RAY DIFFRACTION (3.323 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
8JKE	AfsR(T337A) transcription activation complex Descriptor: DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2023-06-01 Release date: 2024-02-14 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5XJ0	T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. Deposit date: 2017-04-28 Release date: 2017-12-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.004 Å) Cite: A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation Nucleic Acids Res., 46, 2018
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA Descriptor: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-07-10 Release date: 2022-02-02 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022

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