6CUU

Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A

Summary for 6CUU

• Entry DOI: 10.2210/pdb6cuu/pdb
• Descriptor: DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total)
• Functional Keywords: rna polymerase, kanglemycin a, transcription inhibitor, transcription, transcription-dna-antibiotic complex, transcription/dna/antibiotic
• Biological source: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039); More
• Total number of polymer chains: 8
• Total formula weight: 442899.84

Authors

Molodtsov, V.,Murakami, K.S. (deposition date: 2018-03-26, release date: 2018-07-25, Last modification date: 2024-03-13)

• Primary citation: Mosaei, H.,Molodtsov, V.,Kepplinger, B.,Harbottle, J.,Moon, C.W.,Jeeves, R.E.,Ceccaroni, L.,Shin, Y.,Morton-Laing, S.,Marrs, E.C.L.,Wills, C.,Clegg, W.,Yuzenkova, Y.,Perry, J.D.,Bacon, J.,Errington, J.,Allenby, N.E.E.,Hall, M.J.,Murakami, K.S.,Zenkin, N.; Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.; Mol. Cell, 72:263-274.e5, 2018; PubMed: 30244835; DOI: 10.1016/j.molcel.2018.08.028

Experimental method

X-RAY DIFFRACTION (2.994 Å)