6CUU
Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | DNA-directed RNA polymerase subunit alpha | polymer | 315 | 35056.2 | 2 | UniProt (Q72I32) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) UniProt (by SIFTS) (Q5SHR6) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha |
| 2 | C | DNA-directed RNA polymerase subunit beta | polymer | 1119 | 125436.5 | 1 | UniProt (Q72HM5) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) UniProt (by SIFTS) (Q8RQE9) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta |
| 3 | D | DNA-directed RNA polymerase subunit beta' | polymer | 1524 | 170997.4 | 1 | UniProt (Q72HM6) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) UniProt (by SIFTS) (Q8RQE8) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta' |
| 4 | E | DNA-directed RNA polymerase subunit omega | polymer | 99 | 11533.3 | 1 | UniProt (Q72ID6) Pfam (PF01192) UniProt (by SIFTS) (Q8RQE7) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega |
| 5 | F | RNA polymerase sigma factor SigA | polymer | 423 | 48568.0 | 1 | UniProt (Q72L95) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q5SKW1) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | |
| 6 | G | DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3') | polymer | 22 | 6674.3 | 1 | Bacillus subtilis | ||
| 7 | H | DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3') | polymer | 27 | 8412.4 | 1 | Bacillus subtilis | ||
| 8 | C | Kanglemycin A | non-polymer | 986.1 | 1 | Chemie (KNG) | |||
| 9 | D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 10 | D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
C: 1 - 1119 (UniProt: Q72HM5)
D: 1 - 1524 (UniProt: Q72HM6)
| PDB | External Database | Details |
|---|---|---|
| Thr 958 | Pro 958 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 274 | Gln 274 | conflict |
| Leu 1041 | Met 1041 | conflict |
| Val 1313 | Ala 1313 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 441734.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1165.5 | |
| All* | Total formula weight | 442899.8 |
