6CUX

Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A

Summary for 6CUX

Entry DOI	10.2210/pdb6cux/pdb
Descriptor	DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
Functional Keywords	bacterial rna polymerase, kanglemycin a, transcription inhibitor, transcription, transcription-transcription inhibitor complex, transcription-antibiotic complex, transcription/antibiotic
Biological source	Escherichia coli (strain K12) More
Total number of polymer chains	12
Total formula weight	921162.07
Authors	Molodtsov, V.,Murakami, K.S. (deposition date: 2018-03-26, release date: 2018-07-25, Last modification date: 2020-01-01)
Primary citation	Mosaei, H.,Molodtsov, V.,Kepplinger, B.,Harbottle, J.,Moon, C.W.,Jeeves, R.E.,Ceccaroni, L.,Shin, Y.,Morton-Laing, S.,Marrs, E.C.L.,Wills, C.,Clegg, W.,Yuzenkova, Y.,Perry, J.D.,Bacon, J.,Errington, J.,Allenby, N.E.E.,Hall, M.J.,Murakami, K.S.,Zenkin, N. Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72:263-274.e5, 2018 Cited by PubMed: 30244835 DOI: 10.1016/j.molcel.2018.08.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.104 Å)

Structure validation