2Y3K
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![BU of 2y3k by Molmil](/molmil-images/mine/2y3k) | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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8CE0
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![BU of 8ce0 by Molmil](/molmil-images/mine/8ce0) | N-terminal domain of human apolipoprotein E | Descriptor: | GLYCEROL, Maltodextrin-binding protein,Apolipoprotein E | Authors: | Marek, M, Nemergut, M. | Deposit date: | 2023-02-01 | Release date: | 2023-07-19 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18, 2023
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8CDY
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![BU of 8cdy by Molmil](/molmil-images/mine/8cdy) | N-terminal domain of human apolipoprotein E | Descriptor: | Maltodextrin-binding protein,Apolipoprotein E | Authors: | Marek, M, Nemergut, M. | Deposit date: | 2023-02-01 | Release date: | 2023-07-19 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18, 2023
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6LNM
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![BU of 6lnm by Molmil](/molmil-images/mine/6lnm) | Crystal structure of CASK-CaMK in complex with Mint1-CID | Descriptor: | Amyloid-beta A4 precursor protein-binding family A member 1, Peripheral plasma membrane protein CASK | Authors: | Cai, Q, Zhang, M. | Deposit date: | 2019-12-31 | Release date: | 2020-04-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for the High-Affinity Interaction between CASK and Mint1. Structure, 28, 2020
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8AX8
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![BU of 8ax8 by Molmil](/molmil-images/mine/8ax8) | |
8AX9
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![BU of 8ax9 by Molmil](/molmil-images/mine/8ax9) | |
6KMH
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![BU of 6kmh by Molmil](/molmil-images/mine/6kmh) | The crystal structure of CASK/Mint1 complex | Descriptor: | Amyloid-beta A4 precursor protein-binding family A member 1, CHLORIDE ION, IODIDE ION, ... | Authors: | Li, W, Feng, W. | Deposit date: | 2019-07-31 | Release date: | 2020-08-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov, 6, 2020
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7XSJ
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![BU of 7xsj by Molmil](/molmil-images/mine/7xsj) | The structure of the Mint1/Munc18-1/syntaxin-1 complex | Descriptor: | Amyloid-beta A4 precursor protein-binding family A member 1, Syntaxin-1A, Syntaxin-binding protein 1 | Authors: | Feng, W, Li, W. | Deposit date: | 2022-05-14 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex. Structure, 31, 2023
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2Y2A
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![BU of 2y2a by Molmil](/molmil-images/mine/2y2a) | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | Descriptor: | ACETATE ION, AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y29
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![BU of 2y29 by Molmil](/molmil-images/mine/2y29) | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3J
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![BU of 2y3j by Molmil](/molmil-images/mine/2y3j) | Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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6RHY
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![BU of 6rhy by Molmil](/molmil-images/mine/6rhy) | |
5W3P
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![BU of 5w3p by Molmil](/molmil-images/mine/5w3p) | ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16 | Descriptor: | Amyloid beta A4 protein, Antibody C706 Fab HEAVY CHAIN, Antibody C706 Fab LIGHT CHAIN, ... | Authors: | Teplyakov, A, Obmolova, G, Gilliland, G.L. | Deposit date: | 2017-06-08 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | A coiled conformation of amyloid-beta recognized by antibody C706. Alzheimers Res Ther, 9, 2017
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3SV1
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![BU of 3sv1 by Molmil](/molmil-images/mine/3sv1) | Crystal structure of APP peptide bound rat Mint2 PARM | Descriptor: | Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein | Authors: | Shen, Y, Long, J, Yan, X, Xie, X. | Deposit date: | 2011-07-12 | Release date: | 2012-07-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Open-closed motion of Mint2 regulates APP metabolism J Mol Cell Biol, 5, 2013
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3SUZ
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![BU of 3suz by Molmil](/molmil-images/mine/3suz) | Crystal structure of Rat Mint2 PPC | Descriptor: | Amyloid beta A4 precursor protein-binding family A member 2 | Authors: | Shen, Y, Long, J, Yan, X, Xie, X. | Deposit date: | 2011-07-11 | Release date: | 2012-07-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Open-closed motion of Mint2 regulates APP metabolism J Mol Cell Biol, 5, 2013
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5HQ3
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![BU of 5hq3 by Molmil](/molmil-images/mine/5hq3) | Stable, high-expression variant of human acetylcholinesterase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP | Authors: | Goldenzweig, A, Goldsmith, M, Hill, S.E, Gertman, O, Laurino, P, Ashani, Y, Dym, O, Albeck, S, Unger, T, Prilusky, J, Lieberman, R.L, Aharoni, A, Silman, I, Sussman, J.L, Tawfik, D.S, Fleishman, S.J. | Deposit date: | 2016-01-21 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol.Cell, 63, 2016
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2WK3
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![BU of 2wk3 by Molmil](/molmil-images/mine/2wk3) | |
6O69
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![BU of 6o69 by Molmil](/molmil-images/mine/6o69) | |
5MYK
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![BU of 5myk by Molmil](/molmil-images/mine/5myk) | |
1HZ3
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![BU of 1hz3 by Molmil](/molmil-images/mine/1hz3) | ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) | Descriptor: | A-BETA AMYLOID | Authors: | Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P. | Deposit date: | 2001-01-23 | Release date: | 2001-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J.Struct.Biol., 130, 2000
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1B41
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![BU of 1b41 by Molmil](/molmil-images/mine/1b41) | HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | Authors: | Kryger, G, Harel, M, Shafferman, A, Silman, I, Sussman, J.L. | Deposit date: | 1999-01-05 | Release date: | 2001-01-17 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr.,Sect.D, 56, 2000
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5MYO
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![BU of 5myo by Molmil](/molmil-images/mine/5myo) | Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb | Descriptor: | Amyloid beta A4 protein, Fab c#6 heavy chain, Fab c#6 light chain, ... | Authors: | Parthier, C, Piechotta, A, Stubbs, M.T. | Deposit date: | 2017-01-27 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
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2M38
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![BU of 2m38 by Molmil](/molmil-images/mine/2m38) | PTB domain of AIDA1 | Descriptor: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B | Authors: | Donaldson, L. | Deposit date: | 2013-01-14 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. Plos One, 8, 2013
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7WVY
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![BU of 7wvy by Molmil](/molmil-images/mine/7wvy) | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | Descriptor: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | Deposit date: | 2022-02-11 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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2BP4
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![BU of 2bp4 by Molmil](/molmil-images/mine/2bp4) | Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Zirah, S, Kozin, S.A, Mazur, A.K, Blond, A, Cheminant, M, Segalas-Milazzo, I, Debey, P, Rebuffat, S. | Deposit date: | 2005-04-18 | Release date: | 2005-04-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Changes of Region 1-16 of the Alzheimer Disease Amyloid Beta-Peptide Upon Zinc Binding and in Vitro Aging. J.Biol.Chem., 281, 2006
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