5MYO
Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb
Summary for 5MYO
Entry DOI | 10.2210/pdb5myo/pdb |
Descriptor | Fab c#6 light chain, Fab c#6 heavy chain, Amyloid beta A4 protein, ... (6 entities in total) |
Functional Keywords | alzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system |
Biological source | Mus musculus (House mouse) More |
Total number of polymer chains | 5 |
Total formula weight | 99304.46 |
Authors | Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-27, release date: 2017-06-28, Last modification date: 2024-01-17) |
Primary citation | Piechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T. Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292:12713-12724, 2017 Cited by PubMed: 28623233DOI: 10.1074/jbc.M117.777839 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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