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5MYO

Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb

Summary for 5MYO
Entry DOI10.2210/pdb5myo/pdb
DescriptorFab c#6 light chain, Fab c#6 heavy chain, Amyloid beta A4 protein, ... (6 entities in total)
Functional Keywordsalzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system
Biological sourceMus musculus (House mouse)
More
Total number of polymer chains5
Total formula weight99304.46
Authors
Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-27, release date: 2017-06-28, Last modification date: 2024-01-17)
Primary citationPiechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T.
Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292:12713-12724, 2017
Cited by
PubMed: 28623233
DOI: 10.1074/jbc.M117.777839
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.59 Å)
Structure validation

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