5MYO
Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ARG160 |
| A | GLU190 |
| A | ARG193 |
| A | HIS194 |
| B | TYR27 |
| B | SER28 |
| B | TYR32 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | SER182 |
| A | THR183 |
| A | HOH534 |
| B | THR182 |
| B | SER184 |
| A | LEU165 |
| A | SER181 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| B | SER118 |
| B | ALA119 |
| B | HOH424 |
| B | HOH533 |
| B | HOH571 |
| D | GLU1 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| C | THR10 |
| C | LYS108 |
| C | GLU110 |
| C | LYS147 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| A | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| E | HIS4 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| E | TYR8 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| E | ASP5 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| E | TYR8 |
