8AX9

Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121)

Summary for 8AX9

Entry DOI	10.2210/pdb8ax9/pdb
Descriptor	Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E (2 entities in total)
Functional Keywords	apolipoprotein e, lipid binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	75117.88
Authors	Nemergut, M.,Marek, M. (deposition date: 2022-08-31, release date: 2023-08-30, Last modification date: 2024-03-13)
Primary citation	Nemergut, M.,Marques, S.M.,Uhrik, L.,Vanova, T.,Nezvedova, M.,Gadara, D.C.,Jha, D.,Tulis, J.,Novakova, V.,Planas-Iglesias, J.,Kunka, A.,Legrand, A.,Hribkova, H.,Pospisilova, V.,Sedmik, J.,Raska, J.,Prokop, Z.,Damborsky, J.,Bohaciakova, D.,Spacil, Z.,Hernychova, L.,Bednar, D.,Marek, M. Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18:38-38, 2023 Cited by PubMed: 37280636 DOI: 10.1186/s13024-023-00620-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.549 Å)

Structure validation