8AX9

Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121)

Summary for 8AX9

• Entry DOI: 10.2210/pdb8ax9/pdb
• Descriptor: Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E (2 entities in total)
• Functional Keywords: apolipoprotein e, lipid binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 75117.88

Authors

Nemergut, M.,Marek, M. (deposition date: 2022-08-31, release date: 2023-08-30, Last modification date: 2024-03-13)

Primary citation

Nemergut, M.,Marques, S.M.,Uhrik, L.,Vanova, T.,Nezvedova, M.,Gadara, D.C.,Jha, D.,Tulis, J.,Novakova, V.,Planas-Iglesias, J.,Kunka, A.,Legrand, A.,Hribkova, H.,Pospisilova, V.,Sedmik, J.,Raska, J.,Prokop, Z.,Damborsky, J.,Bohaciakova, D.,Spacil, Z.,Hernychova, L.,Bednar, D.,Marek, M.
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Mol Neurodegener, 18:38-38, 2023

PubMed Abstract: Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer's Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism of its proteinopathy is unknown.

PubMed: 37280636
DOI: 10.1186/s13024-023-00620-9

Experimental method

X-RAY DIFFRACTION (1.549 Å)