8AX8
Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)
Summary for 8AX8
Entry DOI | 10.2210/pdb8ax8/pdb |
Descriptor | Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E (2 entities in total) |
Functional Keywords | apolipoprotein e, lipid binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 75117.88 |
Authors | Nemergut, M.,Marek, M. (deposition date: 2022-08-31, release date: 2023-08-02, Last modification date: 2024-06-19) |
Primary citation | Nemergut, M.,Marques, S.M.,Uhrik, L.,Vanova, T.,Nezvedova, M.,Gadara, D.C.,Jha, D.,Tulis, J.,Novakova, V.,Planas-Iglesias, J.,Kunka, A.,Legrand, A.,Hribkova, H.,Pospisilova, V.,Sedmik, J.,Raska, J.,Prokop, Z.,Damborsky, J.,Bohaciakova, D.,Spacil, Z.,Hernychova, L.,Bednar, D.,Marek, M. Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18:38-38, 2023 Cited by PubMed: 37280636DOI: 10.1186/s13024-023-00620-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.551 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)