8AX8

Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E	polymer	675	75117.9	1	UniProt (P0AEX9) UniProt (P02649) Pfam (PF01547) Pfam (PF01442)	Homo sapiens (human)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Apo-E
2	B (A)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A: -375 - -7 (UniProt: P0AEX9)

PDB	External Database	Details
Gly -375	Ala 24	engineered mutation
Pro -374	Leu 25	engineered mutation
Met -373	Ala 26	engineered mutation
Ala -291	Asp 108	engineered mutation
Ala -290	Lys 109	engineered mutation
Ala -134	Lys 265	engineered mutation
Ala -14	Glu 385	engineered mutation
Ala -11	Lys 388	engineered mutation
Ala -10	Asp 389	engineered mutation
Asn -6	-	linker
Ala -5	-	linker
Ala -4	-	linker
Ala -3	-	linker
Ala -2	-	linker
His -1	-	linker
Met 0	-	linker

A: 1 - 299 (UniProt: P02649)

PDB	External Database	Details
Arg 112	Cys 130	engineered mutation
Ala 257	Phe 275	engineered mutation
Arg 264	Trp 282	engineered mutation
Ala 269	Val 287	engineered mutation
Gln 279	Leu 297	engineered mutation
Glu 287	Val 305	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	75117.9
All*	Total formula weight	75117.9

*Water molecules are not included.