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8AX8

Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001540molecular_functionamyloid-beta binding
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002021biological_processresponse to dietary excess
A0005102molecular_functionsignaling receptor binding
A0005198molecular_functionstructural molecule activity
A0005319molecular_functionlipid transporter activity
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005771cellular_componentmultivesicular body
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006641biological_processtriglyceride metabolic process
A0006707biological_processcholesterol catabolic process
A0006869biological_processlipid transport
A0006874biological_processintracellular calcium ion homeostasis
A0006898biological_processreceptor-mediated endocytosis
A0006979biological_processresponse to oxidative stress
A0007010biological_processcytoskeleton organization
A0007186biological_processG protein-coupled receptor signaling pathway
A0007271biological_processsynaptic transmission, cholinergic
A0007616biological_processlong-term memory
A0008201molecular_functionheparin binding
A0008203biological_processcholesterol metabolic process
A0008289molecular_functionlipid binding
A0008643biological_processcarbohydrate transport
A0010467biological_processgene expression
A0010468biological_processregulation of gene expression
A0010544biological_processnegative regulation of platelet activation
A0010596biological_processnegative regulation of endothelial cell migration
A0010629biological_processnegative regulation of gene expression
A0010875biological_processpositive regulation of cholesterol efflux
A0010877biological_processlipid transport involved in lipid storage
A0010976biological_processpositive regulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015909biological_processlong-chain fatty acid transport
A0016020cellular_componentmembrane
A0016209molecular_functionantioxidant activity
A0017038biological_processprotein import
A0019068biological_processvirion assembly
A0019899molecular_functionenzyme binding
A0030195biological_processnegative regulation of blood coagulation
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0031012cellular_componentextracellular matrix
A0031175biological_processneuron projection development
A0032438biological_processmelanosome organization
A0032489biological_processregulation of Cdc42 protein signal transduction
A0032805biological_processpositive regulation of low-density lipoprotein particle receptor catabolic process
A0033344biological_processcholesterol efflux
A0033700biological_processphospholipid efflux
A0034360cellular_componentchylomicron remnant
A0034361cellular_componentvery-low-density lipoprotein particle
A0034362cellular_componentlow-density lipoprotein particle
A0034363cellular_componentintermediate-density lipoprotein particle
A0034364cellular_componenthigh-density lipoprotein particle
A0034365cellular_componentdiscoidal high-density lipoprotein particle
A0034372biological_processvery-low-density lipoprotein particle remodeling
A0034374biological_processlow-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034380biological_processhigh-density lipoprotein particle assembly
A0034382biological_processchylomicron remnant clearance
A0034384biological_processhigh-density lipoprotein particle clearance
A0034447biological_processvery-low-density lipoprotein particle clearance
A0035641biological_processlocomotory exploration behavior
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0042157biological_processlipoprotein metabolic process
A0042158biological_processlipoprotein biosynthetic process
A0042159biological_processlipoprotein catabolic process
A0042311biological_processvasodilation
A0042470cellular_componentmelanosome
A0042627cellular_componentchylomicron
A0042632biological_processcholesterol homeostasis
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0042982biological_processamyloid precursor protein metabolic process
A0043025cellular_componentneuronal cell body
A0043083cellular_componentsynaptic cleft
A0043254biological_processregulation of protein-containing complex assembly
A0043395molecular_functionheparan sulfate proteoglycan binding
A0043407biological_processnegative regulation of MAP kinase activity
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0043691biological_processreverse cholesterol transport
A0044794biological_processpositive regulation by host of viral process
A0044877molecular_functionprotein-containing complex binding
A0045088biological_processregulation of innate immune response
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045541biological_processnegative regulation of cholesterol biosynthetic process
A0045807biological_processpositive regulation of endocytosis
A0045893biological_processpositive regulation of DNA-templated transcription
A0046889biological_processpositive regulation of lipid biosynthetic process
A0046907biological_processintracellular transport
A0046911molecular_functionmetal chelating activity
A0046983molecular_functionprotein dimerization activity
A0048018molecular_functionreceptor ligand activity
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0048844biological_processartery morphogenesis
A0050709biological_processnegative regulation of protein secretion
A0050728biological_processnegative regulation of inflammatory response
A0050750molecular_functionlow-density lipoprotein particle receptor binding
A0050807biological_processregulation of synapse organization
A0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
A0051246biological_processregulation of protein metabolic process
A0051248biological_processnegative regulation of protein metabolic process
A0051651biological_processmaintenance of location in cell
A0055085biological_processtransmembrane transport
A0055088biological_processlipid homeostasis
A0055089biological_processfatty acid homeostasis
A0055090biological_processacylglycerol homeostasis
A0060228molecular_functionphosphatidylcholine-sterol O-acyltransferase activator activity
A0060999biological_processpositive regulation of dendritic spine development
A0061136biological_processregulation of proteasomal protein catabolic process
A0061771biological_processresponse to caloric restriction
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070326molecular_functionvery-low-density lipoprotein particle receptor binding
A0070328biological_processtriglyceride homeostasis
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071402biological_processcellular response to lipoprotein particle stimulus
A0071682cellular_componentendocytic vesicle lumen
A0071813molecular_functionlipoprotein particle binding
A0071830biological_processtriglyceride-rich lipoprotein particle clearance
A0071831biological_processintermediate-density lipoprotein particle clearance
A0072359biological_processcirculatory system development
A0072562cellular_componentblood microparticle
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090181biological_processregulation of cholesterol metabolic process
A0090205biological_processpositive regulation of cholesterol metabolic process
A0090209biological_processnegative regulation of triglyceride metabolic process
A0097006biological_processregulation of plasma lipoprotein particle levels
A0097113biological_processAMPA glutamate receptor clustering
A0097114biological_processNMDA glutamate receptor clustering
A0097487cellular_componentmultivesicular body, internal vesicle
A0098869biological_processcellular oxidant detoxification
A0098978cellular_componentglutamatergic synapse
A0120020molecular_functioncholesterol transfer activity
A0140077biological_processpositive regulation of lipoprotein transport
A1900221biological_processregulation of amyloid-beta clearance
A1900223biological_processpositive regulation of amyloid-beta clearance
A1900272biological_processnegative regulation of long-term synaptic potentiation
A1902430biological_processnegative regulation of amyloid-beta formation
A1902952biological_processpositive regulation of dendritic spine maintenance
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1902995biological_processpositive regulation of phospholipid efflux
A1903002biological_processpositive regulation of lipid transport across blood-brain barrier
A1903561cellular_componentextracellular vesicle
A1905890biological_processregulation of cellular response to very-low-density lipoprotein particle stimulus
A1905906biological_processregulation of amyloid fibril formation
A1905907biological_processnegative regulation of amyloid fibril formation
A1905908biological_processpositive regulation of amyloid fibril formation
A1905920biological_processpositive regulation of CoA-transferase activity
A1990777cellular_componentlipoprotein particle
A2000822biological_processregulation of behavioral fear response
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO-266-ASN-249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:3947350
ChainResidueDetails
ALEU144
AGLY211

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Methionine sulfoxide => ECO:0000250|UniProtKB:P08226
ChainResidueDetails
AMET125

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER129

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:23234360
ChainResidueDetails
ATHR8
ATHR18

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:10452964
ChainResidueDetails
ALYS75

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:2498325
ChainResidueDetails
ATHR194

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:19838169
ChainResidueDetails
ATHR289

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:20511397
ChainResidueDetails
ASER290

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360
ChainResidueDetails
ASER296

226707

PDB entries from 2024-10-30

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