1AUQ
| A1 DOMAIN OF VON WILLEBRAND FACTOR | Descriptor: | A1 DOMAIN OF VON WILLEBRAND FACTOR, CADMIUM ION | Authors: | Emsley, J, Cruz, M, Handin, R, Liddington, R. | Deposit date: | 1997-09-01 | Release date: | 1998-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib. J.Biol.Chem., 273, 1998
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1Q0P
| A domain of Factor B | Descriptor: | Complement factor B, MANGANESE (II) ION | Authors: | Bhattacharya, A.A, Liddington, R.C. | Deposit date: | 2003-07-17 | Release date: | 2004-03-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the A Domain from Complement Factor B Reveals an Integrin-like Open Conformation. STRUCTURE, 12, 2004
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1QCY
| THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1 | Descriptor: | I-DOMAIN OF INTEGRIN ALPHA1BETA1, MAGNESIUM ION | Authors: | Kankare, J.A, Salminen, T.A, Nymalm, Y, Kaepylae, J, Heino, J, Johnson, M.S. | Deposit date: | 1999-05-12 | Release date: | 2003-09-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Jararhagin-derived RKKH Peptides Induce Structural Changes in a1I Domain of Human Integrin a1b1 J.Biol.Chem., 279, 2004
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8FZ4
| The von Willebrand factor A domain of Anthrax toxin receptor 2 | Descriptor: | Anthrax toxin receptor 2, CHLORIDE ION, MAGNESIUM ION | Authors: | Pedroza-Romo, M.J, Soleimani, S, Lewis, A, Smith, T, Brown, S, Doukov, T, Moody, J.D. | Deposit date: | 2023-01-27 | Release date: | 2023-03-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Increasing the bulk of the 1TEL-target linker and retaining the 10×His tag in a 1TEL-CMG2-vWa construct improves crystal order and diffraction limits. Acta Crystallogr D Struct Biol, 79, 2023
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7F49
| von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA | Descriptor: | BT-100, GLYCEROL, von Willebrand factor | Authors: | Zhu, S. | Deposit date: | 2021-06-18 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer J Thromb Haemost., 18, 2020
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7EOW
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7KC5
| X-ray structure of Lfa-1 I domain in complex with BMS-68852 collected at 273 K | Descriptor: | 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid, Integrin alpha-L, MAGNESIUM ION | Authors: | Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. | Deposit date: | 2020-10-05 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
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7KC3
| X-ray structure of Lfa-1 I domain collected at 273 K | Descriptor: | Integrin alpha-L, MAGNESIUM ION | Authors: | Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. | Deposit date: | 2020-10-05 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
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7KC6
| X-ray structure of Lfa-1 I domain in complex with Lovastatin collected at 273 K | Descriptor: | Integrin alpha-L, LOVASTATIN, MAGNESIUM ION | Authors: | Woldeyes, R.A, Hallenbeck, K.K, Pfaff, S.J, Lee, G, Cortez, S.V, Kelly, M.J, Akassoglou, K, Arkin, M.R, Fraser, J.S. | Deposit date: | 2020-10-05 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins To Be Published
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1LFA
| CD11A I-DOMAIN WITH BOUND MN++ | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | Authors: | Leahy, D.J, Qu, A. | Deposit date: | 1995-09-08 | Release date: | 1996-01-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc.Natl.Acad.Sci.USA, 92, 1995
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1MHP
| Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody | Descriptor: | FAB FRAGMENT, light chain, Fab fragment, ... | Authors: | Karpusas, M, Taylor, F, Ferrant, J, Weinreb, P, Garber, E. | Deposit date: | 2002-08-20 | Release date: | 2003-04-15 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the alpha 1 beta 1 Integrin I Domain in Complex with
an Antibody Fab Fragment J.Mol.Biol., 327, 2003
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1MJN
| Crystal Structure of the intermediate affinity aL I domain mutant | Descriptor: | Integrin alpha-L, MAGNESIUM ION | Authors: | Shimaoka, M, Xiao, T, Liu, J.H, Yang, Y.T, Dong, Y.C, Jun, C.D, McCormack, A, Zhang, R.G, Wang, J.H, Springer, T.A. | Deposit date: | 2002-08-28 | Release date: | 2003-01-28 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation Cell(Cambridge,Mass.), 112, 2003
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1JLM
| I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND | Descriptor: | INTEGRIN, MANGANESE (II) ION | Authors: | Lee, J.-O, Liddington, R. | Deposit date: | 1996-04-09 | Release date: | 1997-01-11 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure, 3, 1995
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1M1U
| AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN | Descriptor: | CALCIUM ION, Integrin alpha-M | Authors: | Xiong, J.-P, Li, R, Essafi, M, Stehle, T, Arnaout, M.A. | Deposit date: | 2002-06-20 | Release date: | 2002-08-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J.Biol.Chem., 275, 2000
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1N3Y
| Crystal structure of the alpha-X beta2 integrin I domain | Descriptor: | Integrin alpha-X | Authors: | Vorup-Jensen, T, Ostermeier, C, Shimaoka, M, Hommel, U, Springer, T.A. | Deposit date: | 2002-10-30 | Release date: | 2003-02-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc.Natl.Acad.Sci.USA, 100, 2003
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1MQA
| Crystal structure of high affinity alphaL I domain in the absence of ligand or metal | Descriptor: | Integrin alpha-L | Authors: | Shimaoka, T, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, Zhang, R, Takagi, J, Wang, J.-H, Springer, T.A. | Deposit date: | 2002-09-15 | Release date: | 2003-01-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation Cell(Cambridge,Mass.), 112, 2003
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1MF7
| INTEGRIN ALPHA M I DOMAIN | Descriptor: | INTEGRIN ALPHA M | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-08-09 | Release date: | 2003-05-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
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1MQ9
| Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact | Descriptor: | Integrin alpha-L, MANGANESE (II) ION | Authors: | Shimaoka, M, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, McCormack, A, Zhang, R, Joachimiak, A, Takagi, J, Wang, J.-H, Springer, T.A. | Deposit date: | 2002-09-15 | Release date: | 2003-01-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation Cell(Cambridge,Mass.), 112, 2003
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1N9Z
| INTEGRIN ALPHA M I DOMAIN MUTANT | Descriptor: | Integrin alpha-M, MAGNESIUM ION | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-11-26 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
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1NA5
| INTEGRIN ALPHA M I DOMAIN | Descriptor: | Integrin alpha-M | Authors: | McCleverty, C.J, Liddington, R.C. | Deposit date: | 2002-11-26 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies Biochem.J., 372, 2003
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7ZWH
| VWF Tubules of D1D2 and D'D3A1 domains | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Javitt, G, Fass, D. | Deposit date: | 2022-05-19 | Release date: | 2022-07-13 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion. Blood, 140, 2022
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7P2D
| Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Jensen, R.K, Andersen, G.R. | Deposit date: | 2021-07-05 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the function-modulating effects of nanobody binding to the integrin receptor alpha M beta 2. J.Biol.Chem., 298, 2022
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7AKK
| Structure of a complement factor-receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | Authors: | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | Deposit date: | 2020-10-01 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.395 Å) | Cite: | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor Nat Commun, 13, 2022
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6JP5
| Rabbit Cav1.1-Nifedipine Complex | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Y, Huang, G, Wu, J, Yan, N. | Deposit date: | 2019-03-25 | Release date: | 2019-06-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel. Cell, 177, 2019
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4BJ3
| Integrin alpha2 I domain E318W-collagen complex | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GFOGER PEPTIDE, ... | Authors: | Carafoli, F, Hamaia, S.W, Bihan, D, Hohenester, E, Farndale, R.W. | Deposit date: | 2013-04-16 | Release date: | 2013-11-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.042 Å) | Cite: | An Activating Mutation Reveals a Second Binding Mode of the Integrin Alpha2 I Domain to the Gfoger Motif in Collagens. Plos One, 8, 2013
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