1MHP
Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody
Summary for 1MHP
Entry DOI | 10.2210/pdb1mhp/pdb |
Descriptor | integrin alpha 1, (RESIDUES 169-360), Fab fragment, heavy chain, FAB FRAGMENT, light chain, ... (4 entities in total) |
Functional Keywords | integrin, cell adhesion, receptor, antibody, immune system |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Membrane; Single-pass type I membrane protein: P18614 |
Total number of polymer chains | 6 |
Total formula weight | 136056.04 |
Authors | Karpusas, M.,Taylor, F.,Ferrant, J.,Weinreb, P.,Garber, E. (deposition date: 2002-08-20, release date: 2003-04-15, Last modification date: 2021-10-27) |
Primary citation | Karpusas, M.,Ferrant, J.,Weinreb, P.,Carmillo, A.,Taylor, F.,Garber, E. Crystal Structure of the alpha 1 beta 1 Integrin I Domain in Complex with an Antibody Fab Fragment J.Mol.Biol., 327:1031-1041, 2003 Cited by PubMed: 12662928DOI: 10.1016/S0022-2836(03)00203-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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