1MHP
Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | integrin alpha 1, (RESIDUES 169-360) | polymer | 192 | 21629.5 | 2 | UniProt (P18614) Pfam (PF00092) | Rattus norvegicus (Norway rat) | Laminin and collagen receptor, VLA-1, CD49a |
| 2 | B, E (H, X) | Fab fragment, heavy chain | polymer | 219 | 23141.9 | 2 | Mus musculus (house mouse) | ||
| 3 | C, F (L, Y) | FAB FRAGMENT, light chain | polymer | 212 | 23201.7 | 2 | Mus musculus (house mouse) | ||
| 4 | G, H (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
A, B: 145 - 336 (UniProt: P18614)
| PDB | External Database | Details |
|---|---|---|
| Val 217 | Gly 241 | engineered mutation |
| Gln 218 | Arg 242 | engineered mutation |
| Arg 219 | Gln 243 | engineered mutation |
| Arg 222 | Leu 246 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 135946.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 109.9 | |
| All* | Total formula weight | 136056.0 |
