1MHP

Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	integrin alpha 1, (RESIDUES 169-360)	polymer	192	21629.5	2	UniProt (P18614) Pfam (PF00092) In PDB	Rattus norvegicus (Norway rat)	Laminin and collagen receptor, VLA-1, CD49a
2	H, X	Fab fragment, heavy chain	polymer	219	23141.9	2		Mus musculus (house mouse)
3	L, Y	FAB FRAGMENT, light chain	polymer	212	23201.7	2		Mus musculus (house mouse)
4	A, B	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)

Sequence modifications

A, B: 145 - 336 (UniProt: P18614)

PDB	External Database	Details
Val 217	Gly 241	engineered mutation
Gln 218	Arg 242	engineered mutation
Arg 219	Gln 243	engineered mutation
Arg 222	Leu 246	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	135946.2
Non-Polymers*	Number of molecules	2
	Total formula weight	109.9
All*	Total formula weight	136056.0

*Water molecules are not included.