1LFA

CD11A I-DOMAIN WITH BOUND MN++

Summary for 1LFA

• Entry DOI: 10.2210/pdb1lfa/pdb
• Descriptor: CD11A, MANGANESE (II) ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P20701
• Total number of polymer chains: 2
• Total formula weight: 42827.77

Authors

Leahy, D.J.,Qu, A. (deposition date: 1995-09-08, release date: 1996-01-29, Last modification date: 2024-02-14)

Primary citation

Qu, A.,Leahy, D.J.
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proc.Natl.Acad.Sci.USA, 92:10277-10281, 1995

PubMed Abstract: We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.

PubMed: 7479767
DOI: 10.1073/pnas.92.22.10277

Experimental method

X-RAY DIFFRACTION (1.8 Å)