9EMA
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![BU of 9ema by Molmil](/molmil-images/mine/9ema) | RUVBL1/2 in complex with ATP and CB-6644 inhibitor | Descriptor: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | Deposit date: | 2024-03-07 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
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5FR1
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![BU of 5fr1 by Molmil](/molmil-images/mine/5fr1) | Double acetylated RhoGDI-alpha in complex with RhoA-GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RHO GDP-DISSOCIATION INHIBITOR 1, ... | Authors: | Kuhlmann, N, Wroblowski, S, Lammers, M. | Deposit date: | 2015-12-15 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Rhogdi Alpha Acetylation at K127 and K141 Affects Binding Towards Non-Prenylated Rhoa. Biochemistry, 55, 2016
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9AZP
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![BU of 9azp by Molmil](/molmil-images/mine/9azp) | |
5EMJ
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![BU of 5emj by Molmil](/molmil-images/mine/5emj) | Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin | Descriptor: | (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol, GLYCEROL, Methylosome protein 50, ... | Authors: | Boriack-Sjodin, P.A, Jin, L. | Deposit date: | 2015-11-06 | Release date: | 2016-02-24 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.273 Å) | Cite: | Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
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7S1P
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![BU of 7s1p by Molmil](/molmil-images/mine/7s1p) | PRMT5/MEP50 crystal structure with sinefungin bound | Descriptor: | Methylosome protein 50, Protein arginine N-methyltransferase 5, SINEFUNGIN | Authors: | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | Deposit date: | 2021-09-02 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
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5EMK
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![BU of 5emk by Molmil](/molmil-images/mine/5emk) | |
5D2D
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![BU of 5d2d by Molmil](/molmil-images/mine/5d2d) | Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 | Descriptor: | 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... | Authors: | Stevers, L.M, Leysen, S.F.R, Ottmann, C. | Deposit date: | 2015-08-05 | Release date: | 2016-03-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
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1KO9
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![BU of 1ko9 by Molmil](/molmil-images/mine/1ko9) | Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 | Descriptor: | 8-oxoguanine DNA glycosylase, SULFATE ION | Authors: | Bjoras, M, Seeberg, E, Luna, L, Pearl, L.H, Barrett, T.E. | Deposit date: | 2001-12-20 | Release date: | 2002-01-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. J.Mol.Biol., 317, 2002
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2NOZ
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![BU of 2noz by Molmil](/molmil-images/mine/2noz) | Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*G*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-26 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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5EXA
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![BU of 5exa by Molmil](/molmil-images/mine/5exa) | Small-molecule stabilization of the 14-3-3/Gab2 PPI interface | Descriptor: | 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... | Authors: | Bier, D, Ottmann, C. | Deposit date: | 2015-11-23 | Release date: | 2016-05-04 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
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2NOF
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![BU of 2nof by Molmil](/molmil-images/mine/2nof) | Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*C*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOB
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![BU of 2nob by Molmil](/molmil-images/mine/2nob) | Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*T*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOI
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![BU of 2noi by Molmil](/molmil-images/mine/2noi) | Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*C*CP*AP*GP*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOE
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![BU of 2noe by Molmil](/molmil-images/mine/2noe) | Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA | Descriptor: | 5'-D(*G*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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5EWZ
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![BU of 5ewz by Molmil](/molmil-images/mine/5ewz) | Small-molecule stabilization of the 14-3-3/Gab2 PPI interface | Descriptor: | 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 | Authors: | Bier, D, Ottmann, C. | Deposit date: | 2015-11-23 | Release date: | 2016-05-04 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
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1IG7
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![BU of 1ig7 by Molmil](/molmil-images/mine/1ig7) | Msx-1 Homeodomain/DNA Complex Structure | Descriptor: | 5'-D(*CP*AP*CP*TP*AP*AP*TP*TP*GP*AP*AP*GP*G)-3', 5'-D(P*TP*CP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*TP*GP*AP*C)-3', Homeotic protein Msx-1 | Authors: | Hovde, S, Abate-Shen, C, Geiger, J.H. | Deposit date: | 2001-04-17 | Release date: | 2001-04-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the Msx-1 homeodomain/DNA complex Biochemistry, 40, 2001
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2NOL
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![BU of 2nol by Molmil](/molmil-images/mine/2nol) | Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Banerjee, A, Radom, C.T, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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2NOH
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![BU of 2noh by Molmil](/molmil-images/mine/2noh) | Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine DNA | Descriptor: | 5'-D(*GP*CP*GP*TP*CP*CP*AP*(G42)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', CALCIUM ION, ... | Authors: | Radom, C.T, Banerjee, A, Verdine, G.L. | Deposit date: | 2006-10-25 | Release date: | 2006-11-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J.Biol.Chem., 282, 2007
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1TAC
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![BU of 1tac by Molmil](/molmil-images/mine/1tac) | |
6FCM
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![BU of 6fcm by Molmil](/molmil-images/mine/6fcm) | Crystal structure of human PCNA | Descriptor: | Proliferating cell nuclear antigen | Authors: | Housset, D, Frachet, P. | Deposit date: | 2017-12-20 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. J.Exp.Med., 216, 2019
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3R63
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![BU of 3r63 by Molmil](/molmil-images/mine/3r63) | Structure of ERK2 (SPE) mutant (S246E) | Descriptor: | Mitogen-activated protein kinase 1 | Authors: | Livnah, O, Karamansha, Y. | Deposit date: | 2011-03-21 | Release date: | 2011-08-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation. Mol.Cell.Biol., 31, 2011
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2YPA
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![BU of 2ypa by Molmil](/molmil-images/mine/2ypa) | Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA | Descriptor: | EBOX FORWARD, EBOX REVERSE, LIM DOMAIN-BINDING PROTEIN 1, ... | Authors: | El Omari, K, Hoosdally, S.J, Tuladhar, K, Karia, D, Ponsele, E, Platonova, O, Vyas, P, Patient, R, Porcher, C, Mancini, E.J. | Deposit date: | 2012-10-30 | Release date: | 2013-07-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets. Cell Rep., 4, 2013
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1BW5
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![BU of 1bw5 by Molmil](/molmil-images/mine/1bw5) | THE NMR SOLUTION STRUCTURE OF THE HOMEODOMAIN OF THE RAT INSULIN GENE ENHANCER PROTEIN ISL-1, 50 STRUCTURES | Descriptor: | INSULIN GENE ENHANCER PROTEIN ISL-1 | Authors: | Ippel, J.H, Larsson, G, Behravan, G, Zdunek, J, Lundqvist, M, Schleucher, J, Lycksell, P.-O, Wijmenga, S.S. | Deposit date: | 1998-09-29 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the homeodomain of the rat insulin-gene enhancer protein isl-1. Comparison with other homeodomains. J.Mol.Biol., 288, 1999
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5U8S
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![BU of 5u8s by Molmil](/molmil-images/mine/5u8s) | Structure of eukaryotic CMG helicase at a replication fork | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ... | Authors: | Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E. | Deposit date: | 2016-12-14 | Release date: | 2017-01-25 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (6.101 Å) | Cite: | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3B4V
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![BU of 3b4v by Molmil](/molmil-images/mine/3b4v) | X-Ray structure of Activin in complex with FSTL3 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... | Authors: | Thompson, T.B. | Deposit date: | 2007-10-24 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
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