5EWZ

Small-molecule stabilization of the 14-3-3/Gab2 PPI interface

Summary for 5EWZ

• Entry DOI: 10.2210/pdb5ewz/pdb
• Related: 4FJ3 4IHL 4N7G
• Descriptor: 14-3-3 protein zeta/delta, GRB2-associated-binding protein 2, BENZOIC ACID, ... (5 entities in total)
• Functional Keywords: 14-3-3, gab2, protein, diphosphorylation, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 54749.69

Authors

Bier, D.,Ottmann, C. (deposition date: 2015-11-23, release date: 2016-05-04, Last modification date: 2018-12-19)

• Primary citation: Bier, D.,Bartel, M.,Sies, K.,Halbach, S.,Higuchi, Y.,Haranosono, Y.,Brummer, T.,Kato, N.,Ottmann, C.; Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.; Chemmedchem, 11:911-918, 2016; PubMed: 26644359; DOI: 10.1002/cmdc.201500484

Experimental method

X-RAY DIFFRACTION (2.34 Å)