5D2D

Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768

Summary for 5D2D

• Entry DOI: 10.2210/pdb5d2d/pdb
• Related PRD ID: PRD_900003
• Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: protein-peptide complex, phosphorylation, tandem binding, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 56716.59

Authors

Stevers, L.M.,Leysen, S.F.R.,Ottmann, C. (deposition date: 2015-08-05, release date: 2016-03-16, Last modification date: 2020-07-29)

• Primary citation: Stevers, L.M.,Lam, C.V.,Leysen, S.F.,Meijer, F.A.,van Scheppingen, D.S.,de Vries, R.M.,Carlile, G.W.,Milroy, L.G.,Thomas, D.Y.,Brunsveld, L.,Ottmann, C.; Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.; Proc.Natl.Acad.Sci.USA, 113:E1152-E1161, 2016; PubMed: 26888287; DOI: 10.1073/pnas.1516631113

Experimental method

X-RAY DIFFRACTION (2.1 Å)