5EMJ

Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin

Summary for 5EMJ

• Entry DOI: 10.2210/pdb5emj/pdb
• Related: 5EMK 5EML 5EMM
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, SINEFUNGIN, ... (6 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : O14744; Nucleus: Q9BQA1
• Total number of polymer chains: 2
• Total formula weight: 112789.31

Authors

Boriack-Sjodin, P.A.,Jin, L. (deposition date: 2015-11-06, release date: 2016-02-24, Last modification date: 2018-04-18)

• Primary citation: Duncan, K.W.,Rioux, N.,Boriack-Sjodin, P.A.,Munchhof, M.J.,Reiter, L.A.,Majer, C.R.,Jin, L.,Johnston, L.D.,Chan-Penebre, E.,Kuplast, K.G.,Porter Scott, M.,Pollock, R.M.,Waters, N.J.,Smith, J.J.,Moyer, M.P.,Copeland, R.A.,Chesworth, R.; Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.; ACS Med Chem Lett, 7:162-166, 2016; PubMed: 26985292; DOI: 10.1021/acsmedchemlett.5b00380

Experimental method

X-RAY DIFFRACTION (2.273 Å)