5EMJ
Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein arginine N-methyltransferase 5 | polymer | 645 | 73763.6 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
2 | B | Methylosome protein 50 | polymer | 350 | 37862.4 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
3 | A | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) | |||
4 | A | (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol | non-polymer | 413.5 | 1 | Chemie (5QJ) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
6 | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 2 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 111626.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1163.3 | |
All* | Total formula weight | 112789.3 |