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9EQG
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BU of 9eqg by Molmil
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kasaragod, V.B, Aricescu, A.R.
Deposit date:2024-03-21
Release date:2024-09-18
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:A brain-to-gut signal controls intestinal fat absorption.
Nature, 2024
9JA0
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BU of 9ja0 by Molmil
The capsid protein of HIV 1
Descriptor: Capsid protein p24
Authors:Yi, G, Ma, J, Zhang, P.
Deposit date:2024-08-23
Release date:2024-09-04
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The capsid protein of HIV 1
To Be Published
9JA1
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BU of 9ja1 by Molmil
The RNA polymerase II elongation complex from Saccharomyces cerevisiae
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*CP*TP*CP*CP*TP*TP*CP*TP*CP*CP*CP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*T)-3'), DNA (5'-D(P*TP*GP*GP*GP*AP*GP*AP*AP*GP*GP*AP*GP*C)-3'), ...
Authors:Yi, G, Ma, J, Zhang, P.
Deposit date:2024-08-23
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:The RNA polymerase II elongation complex from Saccharomyces cerevisiae
To Be Published
9BQ2
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BU of 9bq2 by Molmil
Structure of the flotillin complex in a native membrane environment
Descriptor: Flotillin-1, Flotillin-2
Authors:Fu, Z, MacKinnon, R.
Deposit date:2024-05-08
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the flotillin complex in a native membrane environment.
Proc.Natl.Acad.Sci.USA, 121, 2024
8ZL9
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BU of 8zl9 by Molmil
ASFV p72 in complex with Fab G6
Descriptor: B646L, G6 Heavy chain, G6 Light chain
Authors:Wang, X, Fu, W, Yu, Q.
Deposit date:2024-05-17
Release date:2024-09-18
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.36 Å)
Cite:p72 antigenic mapping reveals a potential supersite of vulnerability for African swine fever virus.
Cell Discov, 10, 2024
8BNT
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BU of 8bnt by Molmil
The DH domain of ARHGEF2 bound to RhoA
Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, Rho guanine nucleotide exchange factor 2, ...
Authors:Bradshaw, W.J, Katis, V.L, Grosjean, H, Bountra, C, von Delft, F, Brennan, P.E.
Deposit date:2022-11-25
Release date:2022-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The DH domain of ARHGEF2 bound to RhoA
To Be Published
6V6U
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BU of 6v6u by Molmil
Crystal structure of RhoA-GDP with novel Switch I conformation
Descriptor: 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lin, Y, Zheng, Y.
Deposit date:2019-12-06
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Structure of an inactive conformation of GTP-bound RhoA GTPase.
Structure, 29, 2021
6V6M
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BU of 6v6m by Molmil
Crystal structure of an inactive state of GMPPNP-bound RhoA
Descriptor: 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Lin, Y, Zheng, Y.
Deposit date:2019-12-05
Release date:2020-12-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Structure of an inactive conformation of GTP-bound RhoA GTPase.
Structure, 29, 2021
6V6V
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BU of 6v6v by Molmil
Crystal structure of oncogenic RhoA mutant G14V complexed with GDP
Descriptor: 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lin, Y, Zheng, Y.
Deposit date:2019-12-06
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of an inactive conformation of GTP-bound RhoA GTPase.
Structure, 29, 2021
8D86
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BU of 8d86 by Molmil
Isoreticular, interpenetrating co-crystal of Replication Initiator Protein REPE54 and symmetrical expanded duplex (31mer) containing the cognate REPE54 sequence and an additional G-C rich sequence co-crystallized with a guest small molecule, netropsin.
Descriptor: DNA (5'-D(A*CP*CP*CP*GP*GP*AP*CP*CP*TP*GP*TP*GP*AP*CP*AP*AP*AP*TP*TP*GP*CP*CP*CP*TP*CP*AP*GP*AP*CP*GP*G)-3'), DNA (5'-D(A*GP*GP*CP*CP*GP*TP*CP*TP*GP*AP*GP*GP*GP*CP*AP*AP*TP*TP*TP*GP*TP*CP*AP*CP*AP*GP*GP*TP*CP*CP*G)-3'), MAGNESIUM ION, ...
Authors:Orun, A.R, Snow, C.D.
Deposit date:2022-06-07
Release date:2023-06-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Modular Protein-DNA Cocrystals as Precise, Programmable Assembly Scaffolds.
Acs Nano, 17, 2023
6G2T
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BU of 6g2t by Molmil
human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament
Descriptor: Actin, cytoplasmic 2, Myosin-binding protein C, ...
Authors:Risi, C, Belknap, B, Forgacs, E, Harris, S.P, Schroder, G.F, White, H.D, Galkin, V.E.
Deposit date:2018-03-23
Release date:2018-10-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (9 Å)
Cite:N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Structure, 26, 2018
6KX2
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BU of 6kx2 by Molmil
Crystal structure of GDP bound RhoA protein
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA
Authors:Zhang, H, Luo, C.
Deposit date:2019-09-09
Release date:2020-08-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.454 Å)
Cite:Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
6KX3
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BU of 6kx3 by Molmil
Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, prop-2-enyl (3R)-1,1-bis(oxidanylidene)-2,3-dihydro-1-benzothiophene-3-carboxylate
Authors:Zhang, H, Luo, C.
Deposit date:2019-09-09
Release date:2020-08-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
8DNF
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BU of 8dnf by Molmil
Cryo-EM structure of nonmuscle gamma-actin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ...
Authors:Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K.
Deposit date:2022-07-11
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural insights into actin isoforms.
Elife, 12, 2023
3BS7
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BU of 3bs7 by Molmil
Crystal structure of the Sterile Alpha Motif (SAM) domain of Hyphen/Aveugle
Descriptor: Protein aveugle
Authors:Rajakulendran, T, Sicheri, F.
Deposit date:2007-12-22
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.
Proc.Natl.Acad.Sci.USA, 105, 2008
3BZ3
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BU of 3bz3 by Molmil
Crystal Structure Analysis of Focal Adhesion Kinase with a Methanesulfonamide Diaminopyrimidine Inhibitor
Descriptor: Focal adhesion kinase 1, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide
Authors:Vajdos, F, Marr, E.
Deposit date:2008-01-17
Release date:2008-04-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
Cancer Res., 68, 2008
2R4H
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BU of 2r4h by Molmil
Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase
Descriptor: HISTIDINE, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Authors:Ugochukwu, E, Pilka, E.S, Hozjan, V, Kavanagh, K.L, Cooper, C, Pike, A.C.W, Elkins, J.M, Doyle, D.A, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase.
To be Published
2RGN
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BU of 2rgn by Molmil
Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
Authors:Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G.
Deposit date:2007-10-04
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
6SIU
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BU of 6siu by Molmil
Crystal structure of IbpAFic2 covalently tethered to Cdc42
Descriptor: Cell division control protein 42 homolog, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gulen, B, Roselin, M, Albers, M, Hedberg, C, Itzen, A, Pogenberg, V.
Deposit date:2019-08-12
Release date:2020-03-18
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Nat.Chem., 12, 2020
5ZHX
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BU of 5zhx by Molmil
Crystal structure of SmgGDS-558 and farnesylated RhoA complex
Descriptor: FARNESYL, Rap1 GTPase-GDP dissociation stimulator 1, Transforming protein RhoA
Authors:Shimizu, H, Toma-Fukai, S, Shimizu, T.
Deposit date:2018-03-13
Release date:2018-09-05
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8FG0
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BU of 8fg0 by Molmil
Crystal structure of the 3764 Fab in complex with the C-terminal PfCSP linker, PfCSP281-294.
Descriptor: 3764 Fab Heavy chain, 3764 Fab Light chain, Circumsporozoite protein
Authors:Burn Aschner, C, Julien, J.P.
Deposit date:2022-12-11
Release date:2023-05-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies.
Embo Mol Med, 15, 2023
6OQ3
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BU of 6oq3 by Molmil
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2
Descriptor: 2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ...
Authors:Gingras, A.R.
Deposit date:2019-04-25
Release date:2020-06-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Faseb Bioadv, 2021
6OQ4
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BU of 6oq4 by Molmil
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1
Descriptor: 2-{(Z)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-[(1S)-1-phenylethyl]benzamide, Krev interaction trapped protein 1, MAGNESIUM ION, ...
Authors:Gingras, A.R.
Deposit date:2019-04-25
Release date:2020-06-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Faseb Bioadv, 2021
6OTN
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BU of 6otn by Molmil
Crystal Structure of an N-terminal Fragment of Cancer Associated Tropomyosin 3.1 (Tpm3.1)
Descriptor: SULFATE ION, Tropomyosin alpha-3 chain
Authors:Rynkiewicz, M.J, Ghosh, A, Lehman, W.J, Janco, M, Gunning, P.W.
Deposit date:2019-05-03
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.
Sci Rep, 9, 2019
8FPW
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BU of 8fpw by Molmil
Crystal structure of tumor related RhoA mutant A161V in complex with GDP
Descriptor: 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lin, Y, Zheng, Y.
Deposit date:2023-01-05
Release date:2024-06-05
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.
Nat Commun, 15, 2024

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