6OQ4
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1
Summary for 6OQ4
Entry DOI | 10.2210/pdb6oq4/pdb |
Related | 6OQ3 |
Descriptor | Krev interaction trapped protein 1, Ras-related protein Rap-1b, 2-{(Z)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-[(1S)-1-phenylethyl]benzamide, ... (6 entities in total) |
Functional Keywords | complex, small molecules, gtpase, krit1, cell adhesion |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 57333.82 |
Authors | Gingras, A.R. (deposition date: 2019-04-25, release date: 2020-06-24, Last modification date: 2024-03-13) |
Primary citation | Lopez-Ramirez, M.A.,McCurdy, S.,Li, W.,Haynes, M.K.,Hale, P.,Francisco, K.,Oukoloff, K.,Bautista, M.,Choi, C.H.,Sun, H.,Gongol, B.,Shyy, J.Y.,Ballatore, C.,Sklar, L.A.,Gingras, A.R. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells Faseb Bioadv, 2021 Cited by DOI: 10.1096/fba.2020-00141PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.754 Å) |
Structure validation
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