6OQ4
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005911 | cellular_component | cell-cell junction |
| B | 0007165 | biological_process | signal transduction |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017156 | biological_process | calcium-ion regulated exocytosis |
| B | 0019003 | molecular_function | GDP binding |
| B | 0032486 | biological_process | Rap protein signal transduction |
| B | 0033625 | biological_process | positive regulation of integrin activation |
| B | 0035577 | cellular_component | azurophil granule membrane |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045121 | cellular_component | membrane raft |
| B | 0045955 | biological_process | negative regulation of calcium ion-dependent exocytosis |
| B | 0051649 | biological_process | establishment of localization in cell |
| B | 0061028 | biological_process | establishment of endothelial barrier |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070161 | cellular_component | anchoring junction |
| B | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| B | 0071320 | biological_process | cellular response to cAMP |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099010 | biological_process | modification of postsynaptic structure |
| B | 1901888 | biological_process | regulation of cell junction assembly |
| B | 2000114 | biological_process | regulation of establishment of cell polarity |
| B | 2000301 | biological_process | negative regulation of synaptic vesicle exocytosis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue N0G A 801 |
| Chain | Residue |
| A | GLN473 |
| A | LYS724 |
| A | LYS475 |
| A | TYR477 |
| A | HIS478 |
| A | HIS483 |
| A | VAL512 |
| A | PHE640 |
| A | LYS720 |
| A | LEU721 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 200 |
| Chain | Residue |
| B | SER17 |
| B | THR35 |
| B | GNP201 |
| B | HOH306 |
| B | HOH321 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue GNP B 201 |
| Chain | Residue |
| B | GLY12 |
| B | GLY13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | VAL29 |
| B | GLU30 |
| B | TYR32 |
| B | PRO34 |
| B | THR35 |
| B | GLY60 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER147 |
| B | ALA148 |
| B | MG200 |
| B | HOH306 |
| B | HOH310 |
| B | HOH320 |
| B | HOH321 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Interaction with RAP1B","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18309292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylserine; by botulinum toxin","evidences":[{"source":"PubMed","id":"3141412","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
