6OQ3

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2

Summary for 6OQ3

• Entry DOI: 10.2210/pdb6oq3/pdb
• Related: 6OQ4
• Descriptor: Krev interaction trapped protein 1, Ras-related protein Rap-1b, 2-hydroxynaphthalene-1-carbaldehyde, ... (6 entities in total)
• Functional Keywords: complex, small molecules, gtpase, krit1, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 57111.54

Authors

Gingras, A.R. (deposition date: 2019-04-25, release date: 2020-06-24, Last modification date: 2023-10-11)

• Primary citation: Lopez-Ramirez, M.A.,McCurdy, S.,Li, W.,Haynes, M.K.,Hale, P.,Francisco, K.,Oukoloff, K.,Bautista, M.,Choi, C.H.,Sun, H.,Gongol, B.,Shyy, J.Y.,Ballatore, C.,Sklar, L.A.,Gingras, A.R.; Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells; Faseb Bioadv, 2021; DOI: 10.1096/fba.2020-00141

Experimental method

X-RAY DIFFRACTION (1.85 Å)