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6OQ3

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005856cellular_componentcytoskeleton
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017156biological_processcalcium-ion regulated exocytosis
B0019003molecular_functionGDP binding
B0030033biological_processmicrovillus assembly
B0032486biological_processRap protein signal transduction
B0033625biological_processpositive regulation of integrin activation
B0035577cellular_componentazurophil granule membrane
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0051649biological_processestablishment of localization in cell
B0061028biological_processestablishment of endothelial barrier
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071320biological_processcellular response to cAMP
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B1901888biological_processregulation of cell junction assembly
B2000114biological_processregulation of establishment of cell polarity
B2000301biological_processnegative regulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue 7WO A 801
ChainResidue
AGLN473
ALYS475
AVAL512
APHE640
ALEU717
ALEU721
ALYS724

site_idAC2
Number of Residues5
Detailsbinding site for residue MG B 200
ChainResidue
BGNP201
BHOH305
BHOH306
BSER17
BTHR35

site_idAC3
Number of Residues24
Detailsbinding site for residue GNP B 201
ChainResidue
BGLY12
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BGLU30
BTYR32
BPRO34
BTHR35
BGLY60
BASN116
BLYS117
BASP119
BLEU120
BSER147
BALA148
BLYS149
BMG200
BHOH305
BHOH306

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140
ChainResidueDetails
BGLY10
BASP57
BASN116
BSER147

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412
ChainResidueDetails
BSER39

227111

PDB entries from 2024-11-06

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