6QPI
 
 | | Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc | | Descriptor: | Anoctamin-6 | | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | | Deposit date: | 2019-02-14 | | Release date: | 2019-03-06 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
Elife, 8, 2019
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6R65
 | | Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2) | | Descriptor: | Anoctamin-10, CALCIUM ION | | Authors: | Bushell, S.R, Pike, A.C.W, Chu, A, Tessitore, A, Rotty, B, Mukhopadhyay, S, Kupinska, K, Shrestha, L, Borkowska, O, Chalk, R, Burgess-Brown, N.A, Love, J, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-03-26 | | Release date: | 2019-05-01 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
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6R7X
 | | CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-10, CALCIUM ION, ... | | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Baronina, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-03-29 | | Release date: | 2019-05-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
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6R7Y
 | | CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form) | | Descriptor: | Anoctamin-10, CALCIUM ION | | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-03-29 | | Release date: | 2019-05-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
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6R7Z
 | | CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form) | | Descriptor: | Anoctamin-10 | | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2019-03-29 | | Release date: | 2019-05-01 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (5.14 Å) | | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nat Commun, 10, 2019
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7B5C
 | | Structure of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution | | Descriptor: | Anoctamin-1, CALCIUM ION | | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | | Deposit date: | 2020-12-03 | | Release date: | 2021-02-10 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A.
Nat Commun, 12, 2021
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7B5D
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7B5E
 | | Structure of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution | | Descriptor: | Anoctamin-1, CALCIUM ION | | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | | Deposit date: | 2020-12-03 | | Release date: | 2021-02-10 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A.
Nat Commun, 12, 2021
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7RWJ
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7RX2
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7RX3
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7RXA
 | | afTMEM16 DE/AA mutant in C14 lipid nanodiscs in the presence of Ca2+ | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | | Authors: | Feng, Z, Accardi, A. | | Deposit date: | 2021-08-22 | | Release date: | 2022-05-18 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
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7RXB
 | | afTMEM16 lipid scramblase in C18 lipid nanodiscs in the absence of Ca2+ | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase | | Authors: | Feng, Z, Accardi, A. | | Deposit date: | 2021-08-22 | | Release date: | 2022-05-18 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
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7RXG
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7RXH
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7ZK3
 | | Structure of 1PBC- and calcium-bound mTMEM16A(ac) chloride channel at 2.85 A resolution | | Descriptor: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, Anoctamin-1, CALCIUM ION | | Authors: | Lam, A.K.M, Rutz, S, Dutzler, R. | | Deposit date: | 2022-04-12 | | Release date: | 2022-05-25 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.
Nat Commun, 13, 2022
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8B8G
 | | Cryo-EM structure of Ca2+-free mTMEM16F F518H mutant in Digitonin | | Descriptor: | Anoctamin-6 | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8J
 | | Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8K
 | | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed | | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8M
 | | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8Q
 | | Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8BC0
 | | Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8BC1
 | | Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN | | Descriptor: | Anoctamin-6,mTMEM16F, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8QZC
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8SUN
 | | TMEM16F 1PBC | | Descriptor: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, ... | | Authors: | Wu, H, Feng, S, Cheng, Y. | | Deposit date: | 2023-05-12 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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