8B8K

Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed

Summary for 8B8K

• Entry DOI: 10.2210/pdb8b8k/pdb
• EMDB information: 15916
• Descriptor: Anoctamin-6, CALCIUM ION, 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
• Functional Keywords: membrane protein, lipid transport, lipid scramblase, ion channel, blood coagulation, membrane fusion
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 228215.13

Authors

Arndt, M.,Alvadia, C.,Straub, M.S.,Clerico-Mosina, V.,Paulino, C.,Dutzler, R. (deposition date: 2022-10-04, release date: 2022-11-16)

• Primary citation: Arndt, M.,Alvadia, C.,Straub, M.S.,Clerico Mosina, V.,Paulino, C.,Dutzler, R.; Structural basis for the activation of the lipid scramblase TMEM16F.; Nat Commun, 13:6692-6692, 2022; PubMed: 36335104; DOI: 10.1038/s41467-022-34497-x

Experimental method

ELECTRON MICROSCOPY (3.01 Å)