7RXA

afTMEM16 DE/AA mutant in C14 lipid nanodiscs in the presence of Ca2+

Summary for 7RXA

• Entry DOI: 10.2210/pdb7rxa/pdb
• Related: 7RWJ
• EMDB information: 24717 24722 24723 24726 24727 24730 24731
• Descriptor: afTMEM16 lipid scramblase, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate (2 entities in total)
• Functional Keywords: tmem16, lipid scrambling, lipid transport
• Biological source: Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
• Total number of polymer chains: 2
• Total formula weight: 175021.68

Authors

Feng, Z.,Accardi, A. (deposition date: 2021-08-22, release date: 2022-05-18, Last modification date: 2022-05-25)

• Primary citation: Falzone, M.E.,Feng, Z.,Alvarenga, O.E.,Pan, Y.,Lee, B.,Cheng, X.,Fortea, E.,Scheuring, S.,Accardi, A.; TMEM16 scramblases thin the membrane to enable lipid scrambling.; Nat Commun, 13:2604-2604, 2022; PubMed: 35562175; DOI: 10.1038/s41467-022-30300-z

Experimental method

ELECTRON MICROSCOPY (3.08 Å)