7ZK3

Structure of 1PBC- and calcium-bound mTMEM16A(ac) chloride channel at 2.85 A resolution

Summary for 7ZK3

• Entry DOI: 10.2210/pdb7zk3/pdb
• EMDB information: 14753
• Descriptor: Anoctamin-1, CALCIUM ION, 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (3 entities in total)
• Functional Keywords: calcium-activated chloride channel, anoctamin-1, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 222912.85

Authors

Lam, A.K.M.,Rutz, S.,Dutzler, R. (deposition date: 2022-04-12, release date: 2022-05-25, Last modification date: 2022-06-01)

• Primary citation: Lam, A.K.M.,Rutz, S.,Dutzler, R.; Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.; Nat Commun, 13:2798-2798, 2022; PubMed: 35589730; DOI: 10.1038/s41467-022-30479-1

Experimental method

ELECTRON MICROSCOPY (2.85 Å)