7RX2

afTMEM16 in C22 lipid nanodiscs with MSP1E3 scaffold protein in the presnece of Ca2+

Summary for 7RX2

Entry DOI	10.2210/pdb7rx2/pdb
Related	7RWJ 7RX3 7RXA 7RXB 7RXG
EMDB information	24717 24722 24723 24726 24727 24730 24731
Descriptor	afTMEM16 lipid scramblase, CALCIUM ION, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ... (4 entities in total)
Functional Keywords	tmem16, lipid scrambling, lipid transport
Biological source	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Total number of polymer chains	2
Total formula weight	179880.13
Authors	Falzone, M.E.,Accardi, A. (deposition date: 2021-08-21, release date: 2022-05-18, Last modification date: 2022-05-25)
Primary citation	Falzone, M.E.,Feng, Z.,Alvarenga, O.E.,Pan, Y.,Lee, B.,Cheng, X.,Fortea, E.,Scheuring, S.,Accardi, A. TMEM16 scramblases thin the membrane to enable lipid scrambling. Nat Commun, 13:2604-2604, 2022 Cited by PubMed: 35562175 DOI: 10.1038/s41467-022-30300-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation