8BC1

Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN

Summary for 8BC1

• Entry DOI: 10.2210/pdb8bc1/pdb
• EMDB information: 15959
• Descriptor: Anoctamin-6,mTMEM16F, CALCIUM ION (2 entities in total)
• Functional Keywords: lipid scramblase, ion channel, membrane protein, blood coagulation, viral entry, cell fusion
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 226901.44

Authors

Arndt, M.,Alvadia, C.,Straub, M.S.,Clerico-Mosina, V.,Paulino, C.,Dutzler, R. (deposition date: 2022-10-14, release date: 2022-11-16)

• Primary citation: Arndt, M.,Alvadia, C.,Straub, M.S.,Clerico Mosina, V.,Paulino, C.,Dutzler, R.; Structural basis for the activation of the lipid scramblase TMEM16F.; Nat Commun, 13:6692-6692, 2022; PubMed: 36335104; DOI: 10.1038/s41467-022-34497-x

Experimental method

ELECTRON MICROSCOPY (2.93 Å)