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1UUR
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BU of 1uur by Molmil
Structure of an activated Dictyostelium STAT in its DNA-unbound form
Descriptor: STATA PROTEIN
Authors:Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W.
Deposit date:2004-01-09
Release date:2004-03-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form
Mol.Cell, 13, 2004
7Z3J
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BU of 7z3j by Molmil
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Pinotsis, N, Bunney, T.D, Katan, M.
Deposit date:2022-03-02
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
7YQE
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BU of 7yqe by Molmil
Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54.
Descriptor: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor
Authors:Song, G, Xu, S.
Deposit date:2022-08-06
Release date:2023-08-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
Nat Commun, 15, 2024
4D8K
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BU of 4d8k by Molmil
Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution
Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein kinase Lck
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2012-01-10
Release date:2012-01-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution
To be published
7ZNN
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BU of 7znn by Molmil
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2
Descriptor: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ...
Authors:Lauer, S, Spahn, C.M.T, Schwefel, D.
Deposit date:2022-04-21
Release date:2022-11-09
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
1X27
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BU of 1x27 by Molmil
Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
Descriptor: CRK-associated substrate, Proto-oncogene tyrosine-protein kinase LCK, SODIUM ION
Authors:Nasertorabi, F, Tars, K, Becherer, K, Kodandapani, R, Liljas, L, Vuori, K, Ely, K.R.
Deposit date:2005-04-20
Release date:2006-02-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for regulation of Src by the docking protein p130Cas
J.MOL.RECOG., 19, 2006
7ZN7
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BU of 7zn7 by Molmil
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD
Descriptor: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ...
Authors:Lauer, S, Spahn, C.M.T, Schwefel, D.
Deposit date:2022-04-20
Release date:2022-11-09
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
7ZLS
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BU of 7zls by Molmil
co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13
Descriptor: 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
7ZLN
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BU of 7zln by Molmil
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11
Descriptor: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
7ZLR
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BU of 7zlr by Molmil
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13
Descriptor: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
7ZLM
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BU of 7zlm by Molmil
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551
Descriptor: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
7ZLP
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BU of 7zlp by Molmil
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9
Descriptor: Elongin-B, Elongin-C, PHOSPHATE ION, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
4DGP
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BU of 4dgp by Molmil
The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y.
Deposit date:2012-01-26
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
J.Biol.Chem., 288, 2013
7ZLO
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BU of 7zlo by Molmil
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 12
Descriptor: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ...
Authors:Ramachandran, S, Ciulli, A, Makukhin, N.
Deposit date:2022-04-15
Release date:2023-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Nat Commun, 14, 2023
1XA6
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BU of 1xa6 by Molmil
Crystal Structure of the Human Beta2-Chimaerin
Descriptor: Beta2-chimaerin, ZINC ION
Authors:Canagarajah, B, Leskow, F.C, Ho, J.Y, Mischak, H, Saidi, L.F, Kazanietz, M.G, Hurley, J.H.
Deposit date:2004-08-25
Release date:2004-11-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
Cell(Cambridge,Mass.), 119, 2004
4DGX
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BU of 4dgx by Molmil
LEOPARD Syndrome-Associated SHP2/Y279C mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y.
Deposit date:2012-01-27
Release date:2013-03-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
J.Biol.Chem., 288, 2013
4E68
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BU of 4e68 by Molmil
Unphosphorylated STAT3B core protein binding to dsDNA
Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3
Authors:Collie, G.W, Parkinson, G.N, Shah, R.
Deposit date:2012-03-15
Release date:2013-03-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
Febs Lett., 587, 2013
8AM0
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BU of 8am0 by Molmil
Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib)
Descriptor: (2R)-2-[[2-[(4S)-4-[bis(fluoranyl)methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Goncalves, M, Johnson, J.L, Roewer, K.M.
Deposit date:2022-08-02
Release date:2023-12-13
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:Epinephrine inhibits PI3K alpha via the Hippo kinases.
Cell Rep, 42, 2023
1Y57
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BU of 1y57 by Molmil
Structure of unphosphorylated c-Src in complex with an inhibitor
Descriptor: 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION
Authors:Cowan-Jacob, S.W, Fendrich, G, Manley, P.W, Jahnke, W, Fabbro, D, Liebetanz, J, Meyer, T.
Deposit date:2004-12-02
Release date:2005-06-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation
Structure, 13, 2005
4E93
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BU of 4e93 by Molmil
Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684
Descriptor: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps
Authors:Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2012-03-20
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase.
Chem.Biol., 19, 2012
1Y1U
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BU of 1y1u by Molmil
Structure of unphosphorylated STAT5a
Descriptor: Signal transducer and activator of transcription 5A
Authors:Neculai, D, Neculai, A.M, Verrier, S, Straub, K, Klumpp, K, Pfitzner, E, Becker, S.
Deposit date:2004-11-19
Release date:2005-10-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structure of the unphosphorylated STAT5a dimer
J.Biol.Chem., 280, 2005
4FL3
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BU of 4fl3 by Molmil
Structural and Biophysical Characterization of the Syk Activation Switch
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK
Authors:Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A.
Deposit date:2012-06-14
Release date:2012-11-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biophysical characterization of the syk activation switch.
J.Mol.Biol., 425, 2013
4FL2
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BU of 4fl2 by Molmil
Structural and Biophysical Characterization of the Syk Activation Switch
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK
Authors:Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A.
Deposit date:2012-06-14
Release date:2012-11-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural and biophysical characterization of the syk activation switch.
J.Mol.Biol., 425, 2013
1YVL
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BU of 1yvl by Molmil
Structure of Unphosphorylated STAT1
Descriptor: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta
Authors:Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural bases of unphosphorylated STAT1 association and receptor binding.
Mol.Cell, 17, 2005
3M7F
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BU of 3m7f by Molmil
Crystal structure of the Nedd4 C2/Grb10 SH2 complex
Descriptor: E3 ubiquitin-protein ligase NEDD4, Growth factor receptor-bound protein 10
Authors:Huang, Q, Szebenyi, M.
Deposit date:2010-03-16
Release date:2010-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4.
J.Biol.Chem., 285, 2010

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