2SRC

CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP

Summary for 2SRC

DescriptorTYROSINE-PROTEIN KINASE SRC, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
Functional Keywordssrc, tyrosine-protein kinase, phosphorylation, sh2, sh3, phosphotyrosine, proto-oncogene, phosphotransferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane P12931
Total number of polymer chains1
Total molecular weight52215.77
Authors
Xu, W.,Doshi, A.,Lei, M.,Eck, M.J.,Harrison, S.C. (deposition date: 1998-12-29, release date: 1999-07-22, Last modification date: 2011-07-13)
Primary citation
Xu, W.,Doshi, A.,Lei, M.,Eck, M.J.,Harrison, S.C.
Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3:629-638, 1999
PubMed: 10360179 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(00)80356-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers16 2.2% 12.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02