4ZOP

Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor

Summary for 4ZOP

• Entry DOI: 10.2210/pdb4zop/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2S,3R)-N~1~-(8-tert-butyl-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl)-3-methylpyrrolidine-1,2-dicarboxamide, ... (4 entities in total)
• Functional Keywords: lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 160458.61

Authors

Knapp, M.S.,Elling, R.A. (deposition date: 2015-05-06, release date: 2016-05-18, Last modification date: 2023-09-27)

• Primary citation: Fairhurst, R.A.,Gerspacher, M.,Imbach-Weese, P.,Mah, R.,Caravatti, G.,Fuert, P.,Fritsch, C.,Schnell, C.,Blanz, J.,Blasco, F.,Desrayaud, S.,Guthy, D.A.,Knapp, M.S.,Arz, D.,Wirth, J.,Roehn-Carnemolla, E.,Luu, V.H.; Co-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitorCo-crystal Structure of the Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.62 Å)