2RD0

Structure of a human p110alpha/p85alpha complex

Summary for 2RD0

Entry DOI	10.2210/pdb2rd0/pdb
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total)
Functional Keywords	disease mutation, kinase, oncogene, transferase, host-virus interaction, phosphorylation, sh2 domain, sh3 domain, transferase-oncoprotein complex, transferase/oncoprotein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	161489.54
Authors	Huang, C.,Gabelli, S.B.,Amzel, L.M. (deposition date: 2007-09-20, release date: 2007-12-25, Last modification date: 2024-02-21)
Primary citation	Huang, C.H.,Mandelker, D.,Schmidt-Kittler, O.,Samuels, Y.,Velculescu, V.E.,Kinzler, K.W.,Vogelstein, B.,Gabelli, S.B.,Amzel, L.M. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science, 318:1744-1748, 2007 Cited by PubMed: 18079394 DOI: 10.1126/science.1150799 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation